Protein Alignment pHCl-2 and lgc-36

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001023766.1
• Gene: lgc-36 / 3565335
• WormBaseID: WBGene00008551
• Length: 536
• Species: Caenorhabditis elegans
• Alignment Length: 532
• Identity: 112/532 - (21%)
• Similarity: 224/532 - (42%)
• Gaps: 86/532 - (16%)

  Fly    43 TTDAFSVSINLSQSTVNNC---------------PSLKNAESMALMELLTRLTAPCRYDRMVPPV 92
            :|...||..|..:.|:.|.               |..:...:..:..||..:..  .||:...|.
 Worm    18 STIILSVCGNELKFTIENVKFRSPGSFRIKRTVHPKREKGVAQNVTHLLNNVLK--NYDQHFRPG 80

  Fly    93 VHNKDGEEVPMDIYARFYIYVMKNLDSSDL--QFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGE 155
            .::  |:  |..:|...:|..|..:  |||  .::.....:.::.|.||.|::.....||..:..
 Worm    81 FNS--GK--PTKVYIDLFIRTMGPV--SDLFNTYSFNCYFRQKWTDDRLHFNNSGIGFRQLSLSM 139

  Fly   156 SELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQK 220
            :.|.| :|.|..:..|...|.|.|.:..:.|..:.|:||:|.|:|:.....|.|:..::|.|:|.
 Worm   140 AMLDK-IWKPDTYFWNGAGSYVHGITTSNRLVRLEPDGTILYSSRITVKAKCQMDMSRYPLDKQA 203

  Fly   221 CKTTLESWMYNTTLVQLHWE---TDNPVSFDKQ--LQLTEYNLIGSLYNESIRVSNESYMSHGSL 280
            |:..:.|:.|::..||..|.   .||.|..|.:  ..|.:::|.|....:...::.:.
 Worm   204 CRLVIGSYAYSSDEVQYKWRIMGDDNGVKIDYESIADLPQFSLSGFKVYKPANITRDK------- 261

  Fly   281 EGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSL 345
              .||.:.......|..||:::::::|..::|.:.||:|:.:.:.|..|..:|.|.:|:.:.:|:
 Worm   262 --EYSALEVRFYFDRHFGYFLMNFYVPCALVVLLCWVAFFTKREATAERIGIGITNVLTIVLISM 324

  Fly   346 SQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNN---DLQ-LKKRTTKYIVKSTF 406
            ..:::..||...|..||:..:|.:.....:|||..|:...:.|.   ::| :::...:.|:|.
 Worm   325 DSKSDSPKVDSPTALEVFIWICYLTHLICMVEFTVVHYHTKYNTGDPEIQEVERERLRQIIKQ-- 387

  Fly   407 VPHLKKHR--RHGYRRTDSTMSTMSTTSMDKTCGPNNT--VITIETPIIIGGSLSREDSAISLDE 467
            :|....:|  ...:||.::.:.......:     ||.|  .:::..|       .:.:...|:..
 Worm   388 IPKNTNNRATEPTFRRRNAALPVSIARPL-----PNKTKRFMSVRQP-------KKSEQTESIQL 440

  Fly   468 QDETSTSESSDSSKEKPAQTFATMTPKEVS----LW--------------------IDRKMRFVF 508
            ..:.|..||:..::.:.:....::..:.|.    .|                    ||:....|.
 Worm   441 MRKISNMESTTHNEVESSLNLESIRQENVGWRLYYWMIDHNIKTDPFGVAQNSTSRIDKISVIVA 505

  Fly   509 PLSFIVFNALFW 520
            ||.||:..||::
 Worm   506 PLIFILTIALYY 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	111/529 (21%)
lgc-36	NP_001023766.1	LIC	48..520	CDD:455710	106/502 (21%)
		LGIC_ECD_GABAR_GRD-like	86..275	CDD:349808	48/200 (24%)
		Cys-loop	190..204	CDD:349808	5/13 (38%)