Protein Alignment pHCl-2 and nAChRalpha5

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 561
• Identity: 111/561 - (19%)
• Similarity: 198/561 - (35%)
• Gaps: 152/561 - (27%)

  Fly    26 LQQNLAANGSVVVSPLNTTDAFSVSINLSQSTVNNCPSLKNAESMALM----------------- 73
            |.:.:||:....:|.|.   :|:..:..|.|:.:|..:..|:.|..::
  Fly   241 LFRRIAASTIAFISYLG---SFAAQLRSSSSSSSNSSNSGNSSSTQILNGLNKHSWIFLLIYLNL 302

  Fly    74 ------------ELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDL-QFT 125
                        .||..|..|  |:.:..||::..|    |:.:  .|.:.:|:.:|..:. |..
  Fly   303 SAKVCLAGYHEKRLLHDLLDP--YNTLERPVLNESD----PLQL--SFGLTLMQIIDVDEKNQLL 359

  Fly   126 VQGL-LQLRYLDPRLAF--SSY-------LPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGT 180
            |..: |:|.:.|..|.:  |.|       :|..|            :|.|.:.:.|
  Fly   360 VTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHR------------IWKPDVLMYN--------- 403

  Fly   181 SAKDELTSIYPNGTVLTSTRLQATLY---------CWMNFQKFPFDEQKCKTTLESWMYNTTLVQ 236
            ||.:.....|....|:.:.  .:.||         |.::...||||:|:|:....||.|:...:.
  Fly   404 SADEGFDGTYQTNVVVRNN--GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLD 466

  Fly   237 LHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYV 301
            |..:.:........:...|:.|:|.....     ||.|  :......|..|:|.:::.|...||.
  Fly   467 LQLQDETGGDISSYVLNGEWELLGVPGKR-----NEIY--YNCCPEPYIDITFAIIIRRRTLYYF 524

  Fly   302 IDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSF-ITLSLSQENNLMKVSYVTMSEVWFL 365
            .:..:|.::|.:::.:.|.|..| :..:.:||.|.|||. :.|::..|........|.:...:|.
  Fly   525 FNLIIPCVLIASMALLGFTLPPD-SGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFN 588

  Fly   366 VCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMST 430
            .....:..|:|....:.....||.|........: ||...::|.:.:..|.|
  Fly   589 CIMFMVASSVVSTILILNYHHRNADTHEMSEWIR-IVFLCWLPWILRMSRPG------------- 639

  Fly   431 TSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKE 495
                             .|:|:                 |..|:..||:|.|:..|..:.:..||
  Fly   640 -----------------RPLIL-----------------EFPTTPCSDTSSERKHQILSDVELKE 670

  Fly   496 VS--------LWIDRKMRF----VFPLSFIVFNALFWTLVY 524
            .|        |.||...|.    :.|...:..|..|:..||
  Fly   671 RSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVY 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	104/537 (19%)
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	100/486 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030