DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pHCl-2 and gabrb2a

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001019558.2	Gene:	gabrb2a / 336252	ZFINID:	ZDB-GENE-030131-8196	Length:	519	Species:	Danio rerio

Alignment Length:	526	Identity:	123/526 - (23%)
Similarity:	239/526 - (45%)	Gaps:	91/526 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CP---------SLKNAESMALM-ELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMK 115
            ||         |:::..:|.:: :.:.||..  .||..:.|     |....|:.:.....|..:.
Zfish    14 CPLIVAVACAQSIRDPSNMPVVKDTVDRLMK--GYDIRLRP-----DFGGAPVAVGMNIDIASID 71

  Fly   116 NLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGT 180
            .:...::.:|:....|..:.|.||::|....|    :..::.:...||||..:..|::.|.|.|.
Zfish    72 MVSEVNMDYTLTMYFQQAWRDKRLSYSEIPLN----LTLDNRVADQLWVPDTYFLNDKKSFVHGV 132

  Fly   181 SAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWE-TDNP 244
            :.|:.:..::|:||||...|:..|..|.|:.:::|.|||.|...:||:.|.|..::.:|. .|..
Zfish   133 TVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDGA 197

  Fly   245 VSFDKQLQLTEYNLIG-SLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPS 308
            ||..::::|.:::::. .|.::::..|.          |:|..:|.:..|.|.:||:::..::||
Zfish   198 VSGVERIELPQFSIVDYKLISKNVVFST----------GSYPRLSLSFKLKRNIGYFILQTYMPS 252

  Fly   309 IMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFG 373
            |:|..:||||||:..|.:.||..||.||:|:..|::......|.|:.||...:::.:.|.:|:|.
Zfish   253 ILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFL 317

  Fly   374 SLVEFAFVNTIW----------------RRNNDLQLKKRTTKYIVKS------TFVPHLKKHRRH 416
            :|:|:||||.|:                ..||: :|:....|::|.|      .....:|:....
Zfish   318 ALLEYAFVNYIFFGRGPQRQKKAAEKAATANNE-KLRPDPNKWLVGSVVQRDDALYARMKQREID 381

  Fly   417 GY------------------RRTDSTMS--TMSTTSMDKTCGPN----------NTVITIETPII 451
            ||                  :|...|..  .::|..|....||:          :|::..::..:
Zfish   382 GYDSMWDPIFAEDAALGLGDQRLKMTPDDIRLTTVEMKNEMGPSDLSRGLGDPRSTMLAYDSSTL 446

  Fly   452 --IGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSFIV 514
              ...:::|::...|..|:..|   :.....:.:.:|....:........||:..|.:||..|..
Zfish   447 QYRRAAMARQNYGHSALERHAT---QKKSRLRRRASQLKVNIPDLSDVNSIDKWSRMIFPTLFSF 508

  Fly   515 FNALFW 520
            ||.::|
Zfish   509 FNIVYW 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	123/526 (23%)
gabrb2a	NP_001019558.2	LIC	7..517	CDD:273305	123/526 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810