Protein Alignment pHCl-2 and nAChRbeta3

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Alignment Length: 499
• Identity: 104/499 - (20%)
• Similarity: 162/499 - (32%)
• Gaps: 148/499 - (29%)

  Fly    65 KNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYI-YVMKNLDSSDLQFTVQG 128
            |||...||..|...|..  .||..|.||.     :..|.::.....: |:  ::|..:.:.|...
  Fly    44 KNANVKALDRLHAGLFT--NYDSDVQPVF-----QGTPTNVSLEMVVTYI--DIDELNGKLTTHC 99

  Fly   129 LLQLRYLD-PRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELT----- 187
            .|.||:.| .|:...|...|..|..:..||    :|.|.|.|.|....   |..|:.::|
  Fly   100 WLNLRWRDEERVWQPSQYDNITQITLKSSE----VWTPQITLFNGDEG---GLMAETQVTLSHDG 157

  Fly   188 -------SIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPV 245
                   ::|             |.||.:|...:|.|:|.||..:.||.....|.:........:
  Fly   158 HFRWMPPAVY-------------TAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGESL 209

  Fly   246 SFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIM 310
            ..|..:|..|:.::.|             .:|...:..|..:.:|:...|....|....:.|:..
  Fly   210 DHDDLVQSPEWEIVDS-------------RAHFVSQDYYGYMEYTLTAQRRSSMYTAVIYTPASC 261

  Fly   311 IVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSL 375
            ||.::..:|||.......:..:                |.|:               .|.|...|
  Fly   262 IVILALSAFWLPPHMGGEKIMI----------------NGLL---------------IIVIAAFL 295

  Fly   376 VEFAFVNTIWRRNNDLQLKKRTTK--YIVKSTFVPHL------KKHRR----------HGYRRTD 422
            :.||.:..:...|..|.:...:|.  |:..||.|..|      .||:|          ||:..|.
  Fly   296 MYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGKHKRRLPEALRKLLHGHLGTW 360

  Fly   423 STMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQT 487
            ..:|..|||.                          |..|....|.|| ...|.:|..:..|...
  Fly   361 LLLSVFSTTG--------------------------ESQAEKTKEMDE-HPYEEADEQESSPLGI 398

  Fly   488 FATMTPKE---------VSLWIDRKMRFVFPLSFIVFNALFWTL 522
            ..|..|..         ::..:||       :||:.|:..|..|
  Fly   399 NHTEVPGAKANQFDWALLATAVDR-------ISFVSFSLAFLIL 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	103/497 (21%)
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	104/499 (21%)