DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pHCl-2 and CG8916

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	139/554 - (25%)
Similarity:	225/554 - (40%)	Gaps:	94/554 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NGSVVVSPLNTTDAFSVSINLSQSTVNN---CPSLKNAESMALMELLTRLTAPCRYDRMVPPVVH 94
            |||:..|...|..::|.|...:|..|..   ...|....||.|..||.      ||::...|.
  Fly    70 NGSLKRSQNATNLSYSSSEISNQRRVRRKAAADMLSRNISMILENLLK------RYEQSQLPT-- 126

  Fly    95 NKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELK 159
              .|:.||..:.....|..|..:...|:.:::....:..:.|.||:|       :.||...|...
  Fly   127 --HGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSF-------KGPIKSLSLSI 182

  Fly   160 KML---WVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKC 221
            |||   |.|..:..|.:.|.:...:..::|..:..||.:|.|.||.....|.|..|.||.|.|.|
  Fly   183 KMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSC 247

  Fly   222 KTTLESWMYNTTLVQLHWET-DNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYS 285
            ...:.|:.|....:...|:. |:.|||...:.|.:::||..::.....|..         ||::|
  Fly   248 PLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQFDLISMMHRNFTTVRR---------EGDFS 303

  Fly   286 IISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENN 350
            ::.....|.|..||::|..::|.|:||.:||||||:..:.|..|.:|..|::|:..|:||....:
  Fly   304 VLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTD 368

  Fly   351 LMKVSYVTMSEVWFLVCT-IFIFGSLVEFAFVN--TIWRRNNDLQLKKRTTKYIVKSTFVPHLKK 412
            |.||.|.|..: |||:.: ::...:|:|||.|:  |........||:.:.....:.::...|..:
  Fly   369 LPKVKYATALD-WFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIANSLSDHAGE 432

  Fly   413 HRRHGYRRTDSTMSTMSTTSMDK------------------TCGPNNTV-----ITIETPIIIGG 454
            ....|....|......|:...:.                  .|..|:.:     ::::..:...|
  Fly   433 VDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAG 497

  Fly   455 SLSR---------EDSAISLDEQDETSTSE--------------SSDSSKEKPAQTFATMTPKE- 495
            .|.|         :.|.|..:..:.|:.:|              .||:|..|..:..|.....|
  Fly   498 FLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQ 562

  Fly   496 ---------VSLWIDRKMRFVFPLSFIVFNALFW 520
                     ||| |||..|..||:||...|.|:|
  Fly   563 GGANCYVNSVSL-IDRVARIAFPMSFAFLNLLYW 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	134/541 (25%)
CG8916	NP_573090.3	LIC	92..598	CDD:273305	132/532 (25%)
		Neur_chan_LBD	111..315	CDD:280998	57/229 (25%)
		Neur_chan_memb	322..>403	CDD:280999	31/81 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910