DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-2 and glra1

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_005173152.1	Gene:	glra1 / 30676	ZFINID:	ZDB-GENE-991117-1	Length:	459	Species:	Danio rerio

Alignment Length:	499	Identity:	135/499 - (27%)
Similarity:	222/499 - (44%)	Gaps:	80/499 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FSVSINLSQSTV-------NNCPSLKNAESMALMELLTRLTAPCR-YD-------RMVPPVVHNK 96
            |::.|.|.::.|       ....:.|.|..|...|.|.:|..... ||       ::|.|.....
Zfish     2 FALGIYLWETIVFFSLAASQQAAARKAASPMPPSEFLDKLMGKVSGYDARIRPNFKVVDPQGSKS 66

  Fly    97 DG---EEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRR---QPIMGE 155
            ||   :..|:::....:|....::..:.:.:.|...|:.::.|||||:|.| |:..   .|.|.:
Zfish    67 DGTHKKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYSEY-PDDSLDLDPSMLD 130

  Fly   156 SELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQK 220
            |     :|.|.:|..||:.:.....:..::|..|..||.||.|.|:...|.|.|:.:.||.|.|.
Zfish   131 S-----IWKPDLFFANEKGANFHEVTTDNKLLRISKNGNVLYSIRITLVLACPMDLKNFPMDVQT 190

  Fly   221 CKTTLESWMYNTTLVQLHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYS 285
            |...|||:.|....:...|:....|.....|.|.::.|   ...:.:|...:.|.:     |.::
Zfish   191 CIMQLESFGYTMNDLIFEWDEKGAVQVADGLTLPQFIL---KEEKDLRYCTKHYNT-----GKFT 247

  Fly   286 IISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENN 350
            .|.....|.|::|||:|..::||::||.:||||||:..|..|||..||.||:|:..|.|.....:
Zfish   248 CIEARFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRAS 312

  Fly   351 LMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDL---QLKKRTTKYIVKSTFVPHLKK 412
            |.|||||...::|..||.:|:|.:|:|:|.||.|.|::.:|   |.::|            |||:
Zfish   313 LPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFIARQHKELLRFQRRRR------------HLKE 365

  Fly   413 HRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDS-AISLDEQDETSTSES 476
            ......|      .:.:...|...|                  |..:|. ||..:..:..:::..
Zfish   366 DEAGDGR------FSFAAYGMGPAC------------------LQAKDGMAIKGNNNNAPTSTNP 406

  Fly   477 SDSSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
            .:.:.|:..:.|.:...:     ||...|..|||.|::||..:|
Zfish   407 PEKTVEEMRKLFISRAKR-----IDTVSRVAFPLVFLIFNIFYW 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	135/499 (27%)
glra1	XP_005173152.1	LIC	7..448	CDD:273305	133/494 (27%)
		Neur_chan_LBD	38..259	CDD:280998	59/234 (25%)
		Neur_chan_memb	266..445	CDD:280999	63/219 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010