Protein Alignment pHCl-2 and GLRB

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000815.1
• Gene: GLRB / 2743
• HGNCID: 4329
• Length: 497
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 132/492 - (26%)
• Similarity: 230/492 - (46%)
• Gaps: 65/492 - (13%)

  Fly    61 CPSLKNAESMALM------ELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDS 119
            |||.::||.:|.:      .:|.||..  .||..:.|   |..|  :|:|:....:|....::..
Human    39 CPSQQSAEDLARVPANSTSNILNRLLV--SYDPRIRP---NFKG--IPVDVVVNIFINSFGSIQE 96

  Fly   120 SDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKD 184
            :.:.:.|...|:.::.||||...|.. .....:..:..:.|.||.|.:|..||:::.....:.::
Human    97 TTMDYRVNIFLRQKWNDPRLKLPSDF-RGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQEN 160

  Fly   185 ELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPVSFDK 249
            .|..|:.:|.||.|.||..||.|.::...||.|.|:||..|||:.|.|..::..|::.:||..:|
Human   161 ILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEK 225

  Fly   250 QLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTI 314
             :.|.:::    :..|.|...|.:....|:  |.|:.:.....|.|:||:|::..:.|:::||.:
Human   226 -IALPQFD----IKKEDIEYGNCTKYYKGT--GYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVL 283

  Fly   315 SWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFA 379
            ||:|||:..|.:.||..||..::||..:...:....|.|||||...:||.:.|.:|.|.||||:|
Human   284 SWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYA 348

  Fly   380 FVNTIWRRNNDLQLKKR---------------TTKYIVKSTFVP-HLKKHRRHGYRRTDSTMSTM 428
            .|..:......::.:|.               ..|..|..|..| |:            ||:. :
Human   349 VVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHI------------STLQ-V 400

  Fly   429 STTSMDKTCGPNNTVITIETPIIIGGSLSREDSAIS--------LDEQDETSTSESSDSSKEKPA 485
            ..|...|.|...:.:.:.:..|:  |||.| |..:|        ::..:....|::.::.|..||
Human   401 GETRCKKVCTSKSDLRSNDFSIV--GSLPR-DFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPA 462

  Fly   486 QTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFWTL 522
            :.......|.:.|:    .|.:||..|:.||.::|::
Human   463 KPVIPTAAKRIDLY----ARALFPFCFLFFNVIYWSI 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	132/490 (27%)
GLRB	NP_000815.1	LIC	43..496	CDD:455710	129/488 (26%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	51/193 (26%)
		Cys-loop	183..197	CDD:349811	5/13 (38%)