Protein Alignment pHCl-2 and GLRA1

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001139512.1
• Gene: GLRA1 / 2741
• HGNCID: 4326
• Length: 457
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 131/503 - (26%)
• Similarity: 227/503 - (45%)
• Gaps: 99/503 - (19%)

  Fly    47 FSVSINLSQSTVNNCPSLKNAESMALMELLTRLTA-PCRYDRMVPPVVHNKDGEEVPMDIYARFY 110
            ||::.:.......:.|     :.|:..:.|.:|.. ...||..:.|   |..|.  |:::....:
Human    18 FSLAASKEAEAARSAP-----KPMSPSDFLDKLMGRTSGYDARIRP---NFKGP--PVNVSCNIF 72

  Fly   111 IYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRR---QPIMGESELKKMLWVPHIFLTNE 172
            |....::..:.:.:.|...|:.::.|||||::.| |:..   .|.|.:|     :|.|.:|..||
Human    73 INSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEY-PDDSLDLDPSMLDS-----IWKPDLFFANE 131

  Fly   173 QASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQL 237
            :.:.....:..::|..|..||.||.|.|:..||.|.|:.:.||.|.|.|...|||:.|....:..
Human   132 KGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIF 196

  Fly   238 HWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVI 302
            .|:....|.....|.|.::.|   ...:.:|...:.|.:     |.::.|.....|.|::|||:|
Human   197 EWQEQGAVQVADGLTLPQFIL---KEEKDLRYCTKHYNT-----GKFTCIEARFHLERQMGYYLI 253

  Fly   303 DYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVC 367
            ..::||::||.:||:|||:..|..|||..||.||:|:..|.|.....:|.|||||...::|..||
Human   254 QMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVC 318

  Fly   368 TIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTS 432
            .:|:|.:|:|:|.||.:.|::.:| |:.|              :|.|.|
Human   319 LLFVFSALLEYAAVNFVSRQHKEL-LRFR--------------RKRRHH---------------- 352

  Fly   433 MDKTCGPNNTVITIETPIIIGGSLSREDSA--------------ISLDEQDETSTSESSDSSKEK 483
                          ::|::   :|.:||.|              ..|..:|..|...:::|:...
Human   353 --------------KSPML---NLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTN 400

  Fly   484 PAQTFATMTPKEV-------SLWIDRKMRFVFPLSFIVFNALFWTLVY 524
            |... .:.:|:|:       :..||:..|..||::|::||..:| ::|
Human   401 PPPA-PSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYW-IIY 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	130/499 (26%)
GLRA1	NP_001139512.1	LIC	7..446	CDD:273305	130/501 (26%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	230..235		2/9 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..410		2/19 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910