Protein Alignment pHCl-2 and GABRR2

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_002034.3
• Gene: GABRR2 / 2570
• HGNCID: 4091
• Length: 465
• Species: Homo sapiens
• Alignment Length: 439
• Identity: 121/439 - (27%)
• Similarity: 208/439 - (47%)
• Gaps: 63/439 - (14%)

  Fly    98 GEEVPMDIYARFYIYVMKNLDS---SDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELK 159
            |..:|:.:..:     :::|||   .|:.||:...|:..:.|.|||||| ..|:.....|  .|.
Human    74 GPAIPVGVDVQ-----VESLDSISEVDMDFTMTLYLRHYWKDERLAFSS-ASNKSMTFDG--RLV 130

  Fly   160 KMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTT 224
            |.:|||.:|..:.:.|....|:..:.:..::|:|.||.|.|:..|..|.|:|..||.|.|.|...
Human   131 KKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLE 195

  Fly   225 LESWMYNTTLVQLHWET-DNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIIS 288
            |||:.|....:.|:|:. |..:..|:::.|::: ||...:..| |::  .|.|.|.....|  |:
Human   196 LESYAYTDEDLMLYWKNGDESLKTDEKISLSQF-LIQKFHTTS-RLA--FYSSTGWYNRLY--IN 254

  Fly   289 FTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMK 353
            ||  |.|.:.::::..:.|:.::|.:||||||:.....|||.:||.||:|:..|:......::.:
Human   255 FT--LRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPR 317

  Fly   354 VSYVTMSEVWFLVCTIFIFGSLVEFAFVN---TIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRR 415
            ||||...:::..|..:|:|.|::|:|.||   |:..|..    :|...|:......: |.|....
Human   318 VSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKE----RKLREKFPCMCGML-HSKTMML 377

  Fly   416 HGYRRTDSTMSTMSTTSMDKTCG-PNNTVITIETPIIIGGSLSREDS-AISLDEQDETSTSESSD 478
            .|         :.|.:..:...| |.:.::|.|         .|:|. .:.|....|.:.:....
Human   378 DG---------SYSESEANSLAGYPRSHILTEE---------ERQDKIVVHLGLSGEANAARKKG 424

  Fly   479 SSKEKPA-----QTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFWTL 522
            ..|.:..     .|.|          ||:..|.:||.|:|.||.::|::
Human   425 LLKGQTGFRIFQNTHA----------IDKYSRLIFPASYIFFNLIYWSV 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	121/437 (28%)
GABRR2	NP_002034.3	LIC	51..464	CDD:455710	121/439 (28%)
		LGIC_ECD_GABAAR_rho	76..261	CDD:349806	62/200 (31%)
		Cys-loop	178..192	CDD:349806	7/13 (54%)