Protein Alignment pHCl-2 and GABRP

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_055026.1
• Gene: GABRP / 2568
• HGNCID: 4089
• Length: 440
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 132/491 - (26%)
• Similarity: 214/491 - (43%)
• Gaps: 99/491 - (20%)

  Fly    47 FSVSINLSQSTVNNCPSLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYI 111
            |:|.:..|...  :.|..:|            |||  .|::.:.|   |..||  |:.|.....|
Human    26 FNVEVGRSDKL--SLPGFEN------------LTA--GYNKFLRP---NFGGE--PVQIALTLDI 69

  Fly   112 YVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQAST 176
            ..:.::..|::.:|....|:.|::|.||.|..   |:...:  ::.|.:.||||..::...:.|.
Human    70 ASISSISESNMDYTATIYLRQRWMDQRLVFEG---NKSFTL--DARLVEFLWVPDTYIVESKKSF 129

  Fly   177 VLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWET 241
            :...:..:.|..::.|||||.:.|:..|:.|.|:..|:|.|.|.||..||||.|:...|:..|..
Human   130 LHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLR 194

  Fly   242 DN-PVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYF 305
            .| .|...:.|:|.:|. |...:....|...|:        |||:.:.....|.|.|.|::::.:
Human   195 GNDSVRGLEHLRLAQYT-IERYFTLVTRSQQET--------GNYTRLVLQFELRRNVLYFILETY 250

  Fly   306 LPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVS-YVTMSEVWFLVCTI 369
            :||..:|.:||||||:..|..||||.:|.||:||..||.:....:|...: ::...:|:..:|..
Human   251 VPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFS 315

  Fly   370 FIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMD 434
            |:||:|:|:|                           |.|.            |::..|:.
Human   316 FVFGALLEYA---------------------------VAHY------------SSLQQMAA---- 337

  Fly   435 KTCGPNNTVITIETPIIIGGSLS---REDS----AISLDEQDETS-TSESSDSSK----EKPAQT 487
            |..|....|..:....||..|:|   |:.|    .||.|..|.:. |.::||..|    ||..:.
Human   338 KDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRI 402

  Fly   488 ---FATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
               |....|..|    |...:.:|||.|::.|..:|
Human   403 VDYFTIQNPSNV----DHYSKLLFPLIFMLANVFYW 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	132/491 (27%)
GABRP	NP_055026.1	LIC	43..437	CDD:455710	128/472 (27%)
		LGIC_ECD	60..241	CDD:475126	53/194 (27%)