DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-2 and GABRP

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_055026.1	Gene:	GABRP / 2568	HGNCID:	4089	Length:	440	Species:	Homo sapiens

Alignment Length:	491	Identity:	132/491 - (26%)
Similarity:	214/491 - (43%)	Gaps:	99/491 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FSVSINLSQSTVNNCPSLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYI 111
            |:|.:..|...  :.|..:|            |||  .|::.:.|   |..||  |:.|.....|
Human    26 FNVEVGRSDKL--SLPGFEN------------LTA--GYNKFLRP---NFGGE--PVQIALTLDI 69

  Fly   112 YVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQAST 176
            ..:.::..|::.:|....|:.|::|.||.|..   |:...:  ::.|.:.||||..::...:.|.
Human    70 ASISSISESNMDYTATIYLRQRWMDQRLVFEG---NKSFTL--DARLVEFLWVPDTYIVESKKSF 129

  Fly   177 VLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWET 241
            :...:..:.|..::.|||||.:.|:..|:.|.|:..|:|.|.|.||..||||.|:...|:..|..
Human   130 LHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLR 194

  Fly   242 DN-PVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYF 305
            .| .|...:.|:|.:|. |...:....|...|:        |||:.:.....|.|.|.|::::.:
Human   195 GNDSVRGLEHLRLAQYT-IERYFTLVTRSQQET--------GNYTRLVLQFELRRNVLYFILETY 250

  Fly   306 LPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVS-YVTMSEVWFLVCTI 369
            :||..:|.:||||||:..|..||||.:|.||:||..||.:....:|...: ::...:|:..:|..
Human   251 VPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFS 315

  Fly   370 FIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMD 434
            |:||:|:|:|                           |.|.            |::..|:.
Human   316 FVFGALLEYA---------------------------VAHY------------SSLQQMAA---- 337

  Fly   435 KTCGPNNTVITIETPIIIGGSLS---REDS----AISLDEQDETS-TSESSDSSK----EKPAQT 487
            |..|....|..:....||..|:|   |:.|    .||.|..|.:. |.::||..|    ||..:.
Human   338 KDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRI 402

  Fly   488 ---FATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
               |....|..|    |...:.:|||.|::.|..:|
Human   403 VDYFTIQNPSNV----DHYSKLLFPLIFMLANVFYW 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	132/491 (27%)
GABRP	NP_055026.1	Neur_chan_LBD	43..437	CDD:332142	128/472 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4221
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860