Protein Alignment pHCl-2 and GABRG3

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_011519732.1
• Gene: GABRG3 / 2567
• HGNCID: 4088
• Length: 473
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 119/477 - (24%)
• Similarity: 214/477 - (44%)
• Gaps: 67/477 - (14%)

  Fly    62 PSLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTV 126
            |..::.:...::..|.|     .||:.:.|.:..|     |..|....|:..:..:.|.::::.:
Human    40 PKSQDTDVTLILNKLLR-----EYDKKLRPDIGIK-----PTVIDVDIYVNSIGPVSSINMEYQI 94

  Fly   127 QGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYP 191
            .......:.|.||.|:|.:    :.:...|.:..::|:|.....|.:.:.....:..::|..|:.
Human    95 DIFFAQTWTDSRLRFNSTM----KILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWN 155

  Fly   192 NGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPVSFD-KQLQLTE 255
            :|.:|.:.||.....|.:....||.||..|.....|:.|....:...|..::..:.| |..:|.:
Human   156 DGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQ 220

  Fly   256 YNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFW 320
            ::.:| |.|.:..|:..:        |:|.:::....|:|.:||:.|..::|.|:.|.:||||||
Human   221 FDFMG-LRNTTEIVTTSA--------GDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFW 276

  Fly   321 LQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVN--T 383
            ::.|.|||||.||.||:|:..|||.....:|.:|||||..:::..||.:|:|.:|:|:|.:|  :
Human   277 IKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYS 341

  Fly   384 IWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYR---RTDSTMSTMSTTSMDKTCGPNNTVIT 445
            ..|       |..|||   |:|.:.|....|....|   :..|....:...|:.....|...:||
Human   342 SCR-------KPTTTK---KTTSLLHPDSSRWIPERISLQAPSVRIALQNYSLLDMRPPPTAMIT 396

  Fly   446 IETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKEVS------------L 498
            :             ::::...|.::|...|..|.   |..|:|.....:..|            |
Human   397 L-------------NNSVYWQEFEDTCVYECLDG---KDCQSFFCCYEECKSGSWRKGRIHIDIL 445

  Fly   499 WIDRKMRFVFPLSFIVFNALFW 520
            .:|...|..||.||::||.::|
Human   446 ELDSYSRVFFPTSFLLFNLVYW 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	119/477 (25%)
GABRG3	XP_011519732.1	Neur_chan_LBD	48..253	CDD:280998	45/227 (20%)
		LIC	50..470	CDD:273305	118/467 (25%)
		Neur_chan_memb	260..467	CDD:280999	69/232 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810