Protein Alignment pHCl-2 and GABRG2

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 131/571 - (22%)
• Similarity: 223/571 - (39%)
• Gaps: 138/571 - (24%)

  Fly     3 TLGIFVLIS-YLGLSSAAGVHLGDLQQNLAANGSVVVSPLNTTDAFSVSINLSQSTVNNCPSLKN 66
            |:.|.:|:| |.|.:|...   .|..::.|:|.:.|::|.......:|.:|
Human    24 TVWILLLLSLYPGFTSQKS---DDDYEDYASNKTWVLTPKVPEGDVTVILN-------------- 71

  Fly    67 AESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQ 131
                .|:|         .||..:.|.:..|     |..|:...|:..:..:::.::::|:.....
Human    72 ----NLLE---------GYDNKLRPDIGVK-----PTLIHTDMYVNSIGPVNAINMEYTIDIFFA 118

  Fly   132 LRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVL 196
            ..:.|.||.|:|.:...|.    .|.:...:|:|..|..|.:.:.....:..:.:..|:.:|.||
Human   119 QTWYDRRLKFNSTIKVLRL----NSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL 179

  Fly   197 TSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYN-------TTLVQLHW------ETDNP---- 244
            .:.||.....|.:....||.||..|.....||..:       :.::..|:      .||.|
Human   180 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLAS 244

  Fly   245 ------------------------VSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYS 285
                                    |...:..:|.:::.:| |.|.:..|...|        |:|.
Human   245 RVAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVG-LRNTTEVVKTTS--------GDYV 300

  Fly   286 IISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENN 350
            ::|....|:|.:||:.|..::|..:||.:||||||:..|..||||:||.||:|:..|||.....:
Human   301 VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKS 365

  Fly   351 LMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRR 415
            |.||||||..:::..||.||:|.:|||:.                 |..|     ||.:.|..:.
Human   366 LPKVSYVTAMDLFVSVCFIFVFSALVEYG-----------------TLHY-----FVSNRKPSKD 408

  Fly   416 HGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSS 480
            ...::.:..:...|..:......|.:..|.:             ::|..|.|:||....|..|.
Human   409 KDKKKKNPLLRMFSFKAPTIDIRPRSATIQM-------------NNATHLQERDEEYGYECLDG- 459

  Fly   481 KEKPAQTFATMTPKEVSLW-----------IDRKMRFVFPLSFIVFNALFW 520
             :..|..|..........|           :|...|..||.:|.:||.::|
Human   460 -KDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYW 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	119/527 (23%)
GABRG2	NP_944493.2	LIC	69..512	CDD:273305	118/523 (23%)
		Neur_chan_LBD	69..312	CDD:280998	52/287 (18%)
		Neur_chan_memb	319..509	CDD:280999	62/226 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810