Protein Alignment pHCl-2 and GABRB1

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000803.2
• Gene: GABRB1 / 2560
• HGNCID: 4081
• Length: 474
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 116/533 - (21%)
• Similarity: 218/533 - (40%)
• Gaps: 141/533 - (26%)

  Fly    63 SLKNAESMALMELLTRLTAPC-----------------------RYDRMVPPVVHNKDGEEVPMD 104
            :::|.||:.|:.....:|..|                       .||..:.|     |....|:|
Human     3 TVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRP-----DFGGPPVD 62

  Fly   105 IYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFL 169
            :..|..:..:..:...::.:|:....|..:.|.||::|....|    :..::.:...||||..:.
Human    63 VGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLN----LTLDNRVADQLWVPDTYF 123

  Fly   170 TNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTL 234
            .|::.|.|.|.:.|:.:..::|:||||...|:..|..|.|:.:::|.|||.|...:||:.|.|..
Human   124 LNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDD 188

  Fly   235 VQLHWE-TDNPVSFDKQLQLTEYNLIG-SLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREV 297
            ::.:|. .:..|:...:::|.:::::. .:.::.:..:.          |.|..:|.:..|.|.:
Human   189 IEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTT----------GAYPRLSLSFRLKRNI 243

  Fly   298 GYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEV 362
            ||:::..::||.:|..:||||||:..|.:.||..||.||:|:..|:|......|.|:.||...::
Human   244 GYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDI 308

  Fly   363 WFLVCTIFIFGSLVEFAFVNTIW-----------------RRNNDLQLKK--------------- 395
            :.:.|.:|:|.:|:|:||||.|:                 ...|.|::.|
Human   309 YLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLE 373

  Fly   396 -----------------RTTKYIVKSTFVPHLKK-HRRHGYRRTDSTMSTMSTTSMDKTCGPNNT 442
                             :.|.|...|..:.:.|. ..|..|.|           ::|:...|:.
Human   374 IRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGR-----------ALDRHGVPSK- 426

  Fly   443 VITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLWIDRKMRFV 507
                       |.:.|..|.:.:...|.|..:.                        ||:..|..
Human   427 -----------GRIRRRASQLKVKIPDLTDVNS------------------------IDKWSRMF 456

  Fly   508 FPLSFIVFNALFW 520
            ||::|.:||.::|
Human   457 FPITFSLFNVVYW 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	116/533 (22%)
GABRB1	NP_000803.2	LIC	9..472	CDD:273305	114/527 (22%)
		Agonist binding. /evidence=ECO:0000250	120..122		0/1 (0%)
		Agonist binding. /evidence=ECO:0000250	180..182		1/1 (100%)
		Allosteric effector binding. /evidence=ECO:0000250	290..311		5/20 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810