Protein Alignment pHCl-2 and GABRA6

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 446
• Identity: 121/446 - (27%)
• Similarity: 196/446 - (43%)
• Gaps: 83/446 - (18%)

  Fly   100 EVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKM--- 161
            ||..|||...:    ..:...::::|:....:..:.|.||.|.           |.:|:..:
Human    57 EVKTDIYVTSF----GPVSDVEMEYTMDVFFRQTWTDERLKFG-----------GPTEILSLNNL 106

  Fly   162 ----LWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCK 222
                :|.|..|..|.:.|.....:..::|..|..|||:|.:.||.....|.|....||.|...|.
Human   107 MVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACP 171

  Fly   223 TTLESWMYNTTLVQLHWETDNPVSF---DKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNY 284
            ....|:.|..:.:...|:.....|.   ::...|.:|:|||.      .||:|:..|:   .|.|
Human   172 LKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQ------TVSSETIKSN---TGEY 227

  Fly   285 SIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQEN 349
            .|::....|.|::||::|..:.|.||.|.:|.||||:..:..||||..|.||:|:..|||:|..:
Human   228 VIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARH 292

  Fly   350 NLMKVSYVTMSEVWFL-VCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKH 413
            :|.||||.|..: ||: ||..|:|.:|:|||.||..    .:||.:|...|
Human   293 SLPKVSYATAMD-WFIAVCFAFVFSALIEFAAVNYF----TNLQTQKAKRK-------------- 338

  Fly   414 RRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGS----LSREDSAISLDEQDETSTS 474
                     :..:...|.::.|...|      :|..|::...    |.:..:::||   ...|:|
Human   339 ---------AQFAAPPTVTISKATEP------LEAEIVLHPDSKYHLKKRITSLSL---PIVSSS 385

  Fly   475 ESSDSSKEKPAQTFATMTPKEVS------LWIDRKMRFVFPLSFIVFNALFWTLVY 524
            |::......|......:||..:|      ..||:..|.:||::|..||.::| :||
Human   386 EANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYW-VVY 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	119/442 (27%)
GABRA6	NP_000802.2	LIC	5..440	CDD:455710	119/444 (27%)
		LGIC_ECD_GABAAR_A6	42..239	CDD:349840	48/205 (23%)
		Cys-loop	156..170	CDD:349840	5/13 (38%)