DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-2 and GABRA5

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_000801.1	Gene:	GABRA5 / 2558	HGNCID:	4079	Length:	462	Species:	Homo sapiens

Alignment Length:	497	Identity:	140/497 - (28%)
Similarity:	228/497 - (45%)	Gaps:	92/497 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FSVSINLSQS-TVNNCP--SLKNAESMALMELLTRLTAPC--RYDRMVPPVVHNKDGE---EVPM 103
            |.:|:|||.. ..:..|  |:|: |:...:.:.||:....  .||..:.|.:    ||   :|..
Human    18 FCISMNLSSHFGFSQMPTSSVKD-ETNDNITIFTRILDGLLDGYDNRLRPGL----GERITQVRT 77

  Fly   104 DIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIF 168
            |||...:    ..:..:::::|:....:..:.|.||.|..  |.:|.|:  .:.|...:|.|..|
Human    78 DIYVTSF----GPVSDTEMEYTIDVFFRQSWKDERLRFKG--PMQRLPL--NNLLASKIWTPDTF 134

  Fly   169 LTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTT 233
            ..|.:.|.....:..::|..:..:||:|.:.||..:..|.|..:.||.|...|.....|:.|..:
Human   135 FHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNS 199

  Fly   234 LVQLHW---ETDNPVSFDKQLQLTEYNLIG-SLYNESIRVSNESYMSHGSLEGNYSIISFTVLLT 294
            .|...|   .|.:.|..:...:|.:|:|:| ::..|:|..|.          |.|:|::....|.
Human   200 EVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTST----------GEYTIMTAHFHLK 254

  Fly   295 REVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTM 359
            |::||:||..:||.||.|.:|.|||||..:..||||..|.||:|:..|||:|..|:|.||:|.|.
Human   255 RKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATA 319

  Fly   360 SEVWFL-VCTIFIFGSLVEFAFVNTIWRRN---------NDLQLKKRTTKYIVKSTFVPHLKKHR 414
            .: ||: ||..|:|.:|:|||.||...:|.         ...::||:....:.|||
Human   320 MD-WFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKST--------- 374

  Fly   415 RHGYRRTDSTMSTMSTTSMDKT-CGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSD 478
             :.:  |...||.......::| .|.:||.           |:|.:.|      :::||.|:.:.
Human   375 -NAF--TTGKMSHPPNIPKEQTPAGTSNTT-----------SVSVKPS------EEKTSESKKTY 419

  Fly   479 SSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
            :|..|                ||:..|.|||:.|..||.::|
Human   420 NSISK----------------IDKMSRIVFPVLFGTFNLVYW 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	140/497 (28%)
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	52/219 (24%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	74/231 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..412		10/53 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810