Protein Alignment pHCl-2 and GABRA4

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000800.2
• Gene: GABRA4 / 2557
• HGNCID: 4078
• Length: 554
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 139/561 - (24%)
• Similarity: 218/561 - (38%)
• Gaps: 143/561 - (25%)

  Fly    58 VNNCPSLKNAESMALMELLTRLTAPC--RYD-RMVP----PVVHNKDGEEVPMDIYARFYIYVMK 115
            :|..|.....|.....|..||:....  .|| |:.|    ||.      ||..|||...:    .
Human    30 LNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVT------EVKTDIYVTSF----G 84

  Fly   116 NLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKM-------LWVPHIFLTNEQ 173
            .:...::::|:....:..::|.||.:.           |..|:.::       :|.|..|..|.:
Human    85 PVSDVEMEYTMDVFFRQTWIDKRLKYD-----------GPIEILRLNNMMVTKVWTPDTFFRNGK 138

  Fly   174 ASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLH 238
            .|.....:|.::|..|..|||:|.:.||..:..|.|....||.|...|.....|:.|..:.:...
Human   139 KSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYT 203

  Fly   239 WETDNP---VSFDKQ-LQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGY 299
            | |..|   |...|: ..|.:|:|||.      .||:|:..   |:.|.|.:::....|.|::||
Human   204 W-TKGPEKSVEVPKESSSLVQYDLIGQ------TVSSETIK---SITGEYIVMTVYFHLRRKMGY 258

  Fly   300 YVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWF 364
            ::|..::|.||.|.:|.||||:..:..||||..|.||:|:..|||:|..::|.||||.|..: ||
Human   259 FMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMD-WF 322

  Fly   365 L-VCTIFIFGSLVEFAFVN----------------------------------TIWRRNNDLQLK 394
            : ||..|:|.:|:|||.||                                  .:...|.:|.::
Human   323 IAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMR 387

  Fly   395 KRTTKYI-----------------VKSTFVPHLKKHRRHGYRRTD-------STMSTMSTTSMDK 435
            |||...:                 ..||.|....|.....|..:.       :...|:|......
Human   388 KRTNALVHSESDVGNRTEVGNHSSKSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALP 452

  Fly   436 TCGPNN----------TVITIETPIIIGGSLSREDSAIS-------LDEQDETSTSESSDSSKEK 483
            :..|.:          :|.:..|..:.|..|.|..:.::       |......|....|.|...|
Human   453 SASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSK 517

  Fly   484 PAQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFWTLVY 524
                            ||:..|.:||::|..||.::| :||
Human   518 ----------------IDKYARILFPVTFGAFNMVYW-VVY 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	137/557 (25%)
GABRA4	NP_000800.2	LIC	13..541	CDD:455710	137/559 (25%)
		LGIC_ECD_GABAAR_A4	57..255	CDD:349838	56/228 (25%)
		Cys-loop	172..186	CDD:349838	5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..381		0/30 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..435		5/37 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..471		1/18 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..515		4/19 (21%)