Protein Alignment pHCl-2 and GABRA2

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001317619.1
• Gene: GABRA2 / 2555
• HGNCID: 4076
• Length: 511
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 133/475 - (28%)
• Similarity: 216/475 - (45%)
• Gaps: 69/475 - (14%)

  Fly    85 YDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRR 149
            ||..:.|.:    |:.: .:::...|:.....:..:|:::|:....:.::.|.||.|...:...|
Human    53 YDNRLRPGL----GDSI-TEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILR 112

  Fly   150 QPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKF 214
            .    .:.:...:|.|..|..|.:.|.....:..::|..|..:||:|.:.||.....|.|:.:.|
Human   113 L----NNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDF 173

  Fly   215 PFDEQKCKTTLESWMYNTTLVQLHW---ETDNPVSFDKQLQLTEYNLIG-SLYNESIRVSNESYM 275
            |.|...|.....|:.|.|:.|...|   .:|:........:|.:|:|:| |:..|:|:.|.
Human   174 PMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSST---- 234

  Fly   276 SHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSF 340
                  |.|::::....|.|::||:||..:||.||.|.:|.|||||..:..||||..|.||:|:.
Human   235 ------GEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM 293

  Fly   341 ITLSLSQENNLMKVSYVTMSEVWFL-VCTIFIFGSLVEFAFVNTIWRRN---------ND----- 390
            .|||:|..|:|.||:|.|..: ||: ||..|:|.:|:|||.||...:|.         ||
Human   294 TTLSISARNSLPKVAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKSPSI 357

  Fly   391 ----LQLKKRTTKYIVK------STFV----PHLKKHRRHGYRRTDSTMSTMSTTSMDKTCG--- 438
                :.|...:.|.|::      |.::    |.|.:.:...|........|...:|..:...
Human   358 KAEGITLTYNSVKAILQGAKLIWSKYIAFSWPSLFQEKTLEYLEKWMDCLTFKQSSKKEKASVMI 422

  Fly   439 PNN---TVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLWI 500
            .||   ..:....|     :||: |..:|...:..| |.|.:...:.|||:  |..|...||. |
Human   423 QNNAYAVAVANYAP-----NLSK-DPVLSTISKSAT-TPEPNKKPENKPAE--AKKTFNSVSK-I 477

  Fly   501 DRKMRFVFPLSFIVFNALFW 520
            ||..|.|||:.|..||.::|
Human   478 DRMSRIVFPVLFGTFNLVYW 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	133/475 (28%)
GABRA2	NP_001317619.1	LIC	25..500	CDD:455710	133/475 (28%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	47/214 (22%)
		Cys-loop	166..180	CDD:349836	5/13 (38%)