DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-2 and GABRA1

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_000797.2	Gene:	GABRA1 / 2554	HGNCID:	4075	Length:	456	Species:	Homo sapiens

Alignment Length:	486	Identity:	132/486 - (27%)
Similarity:	208/486 - (42%)	Gaps:	102/486 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PSLKNA---ESMALMELLTRLTAPCRYDRMVPPVVHNKDGE---EVPMDIYARFYIYVMKNLDSS 120
            |||::.   .:.....:|.||..  .||..:.|.:    ||   ||..||:...:    ..:...
Human    29 PSLQDELKDNTTVFTRILDRLLD--GYDNRLRPGL----GERVTEVKTDIFVTSF----GPVSDH 83

  Fly   121 DLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDE 185
            |:::|:....:..:.|.||.|...:...|.    .:.:...:|.|..|..|.:.|.....:..::
Human    84 DMEYTIDVFFRQSWKDERLKFKGPMTVLRL----NNLMASKIWTPDTFFHNGKKSVAHNMTMPNK 144

  Fly   186 LTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNP----VS 246
            |..|..:||:|.:.||.....|.|:.:.||.|...|.....|:.|....|...| |..|    |.
Human   145 LLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEW-TREPARSVVV 208

  Fly   247 FDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMI 311
            .:...:|.:|:|:|...:..|..|:         .|.|.:::....|.|::||:||..:||.||.
Human   209 AEDGSRLNQYDLLGQTVDSGIVQSS---------TGEYVVMTTHFHLKRKIGYFVIQTYLPCIMT 264

  Fly   312 VTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFL-VCTIFIFGSL 375
            |.:|.|||||..:..||||..|.||:|:..|||:|..|:|.||:|.|..: ||: ||..|:|.:|
Human   265 VILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMD-WFIAVCYAFVFSAL 328

  Fly   376 VEFAFVNTIWRRN----------------NDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDST 424
            :|||.||...:|.                .|..:||..|.....:::.|:|        .|.|..
Human   329 IEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNL--------ARGDPG 385

  Fly   425 MSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFA 489
            ::|::.::            |||..                :.:.||...|        |.:||.
Human   386 LATIAKSA------------TIEPK----------------EVKPETKPPE--------PKKTFN 414

  Fly   490 TMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
            :::.      |||..|..|||.|.:||.::|
Human   415 SVSK------IDRLSRIAFPLLFGIFNLVYW 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	132/486 (27%)
GABRA1	NP_000797.2	LIC	14..442	CDD:273305	132/486 (27%)
GABRA1	NP_000797.2	LGIC_ECD_GABAAR_A1	56..249	CDD:349835	48/214 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810