DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pHCl-2 and Glrb

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_445748.1	Gene:	Glrb / 25456	RGDID:	2706	Length:	496	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	131/490 - (26%)
Similarity:	226/490 - (46%)	Gaps:	62/490 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CPSLKNAESMALM------ELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDS 119
            |||.::||.:|.:      .:|.||..  .||..:.|   |..|  :|:|:....:|....::..
  Rat    39 CPSQQSAEDLARVPPNSTSNILNRLLV--SYDPRIRP---NFKG--IPVDVVVNIFINSFGSIQE 96

  Fly   120 SDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKD 184
            :.:.:.|...|:.::.||||...|.. .....:..:..:.|.||.|.:|..||:::.....:.::
  Rat    97 TTMDYRVNIFLRQKWNDPRLKLPSDF-RGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQEN 160

  Fly   185 ELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPVSFDK 249
            .|..|:.:|.||.|.||..||.|.::...||.|.|:||..|||:.|.|..::..|::.:||..:|
  Rat   161 ILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEK 225

  Fly   250 QLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTI 314
             :.|.:::    :..|.|...|.:....|:  |.|:.:.....|.|:||:|::..:.|:::||.:
  Rat   226 -IALPQFD----IKKEDIEYGNCTKYYKGT--GYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVL 283

  Fly   315 SWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFA 379
            ||:|||:..|.:.||..||..::||..:...:....|.|||||...:||.:.|.:|.|.||||:|
  Rat   284 SWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYA 348

  Fly   380 FVNTIWRRNNDLQLKK---------------RTTKYIVKSTFVP-HLKKHRRHGYRRTDSTMSTM 428
            .|..:......::.:|               ...|..|..|..| |:            ||:. :
  Rat   349 VVQVMLNNPKRVEAEKARIAKAEQADGKGGNAAKKNTVNGTGTPVHI------------STLQ-V 400

  Fly   429 STTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLD------EQDETSTSESSDSSKEKPAQT 487
            ..|...|.|...:.:.:.:..|:  |||.|:....:.|      |.:.......:.:.|..||:.
  Rat   401 GETRCKKVCTSKSDLRSNDFSIV--GSLPRDFELSNYDCYGKPIEVNNGLGKPQAKNKKPPPAKP 463

  Fly   488 FATMTPKEVSLWIDRKMRFVFPLSFIVFNALFWTL 522
            ......|.:.|:    .|.:||..|:.||.::|::
  Rat   464 VIPTAAKRIDLY----ARALFPFCFLFFNVIYWSI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	131/488 (27%)
Glrb	NP_445748.1	LIC	43..495	CDD:273305	128/486 (26%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	51/193 (26%)
		Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	247..253		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910