Protein Alignment pHCl-2 and GABRR3

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001099050.1
• Gene: GABRR3 / 200959
• HGNCID: 17969
• Length: 467
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 114/456 - (25%)
• Similarity: 220/456 - (48%)
• Gaps: 67/456 - (14%)

  Fly    82 PCRYDRMVPPVVHNKD----------GEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLD 136
            |.:|:::    :|.:|          |..||:.|  ..::..:.::..:::.||:...|:..:.|
Human    58 PQKYEQL----LHIEDNDFAMRPGFGGSPVPVGI--DVHVESIDSISETNMDFTMTFYLRHYWKD 116

  Fly   137 PRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRL 201
            .||:|.|   ...:.:..:..|.:.:|||.||..:.:.|.:..|:.::.:..::|:|.||.|.|:
Human   117 ERLSFPS---TANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRI 178

  Fly   202 QATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPVSFDKQLQLTEYNLIGSLYNES 266
            ..:..|:|:|.:||.|.|.|...|||:.||...:.|:|:..|     |.|...|:..:...:.|.
Human   179 TVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGN-----KSLNTEEHMSLSQFFIED 238

  Fly   267 IRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTT 331
            ...|  |.::..|..|.|:.:....:|.|.|.::|:..:.|:|::|.:||||||:.....|||.:
Human   239 FSAS--SGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVS 301

  Fly   332 LGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKR 396
            ||.||:|:..|:..:...::.:|||:...:|:..|.::|:|.|::|:|.||.:
Human   302 LGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYL------------ 354

  Fly   397 TTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDS 461
                    |.|...|:.::.|.......:..:...:.| .|..::             .:..:.:
Human   355 --------TTVEERKQFKKTGKISRMYNIDAVQAMAFD-GCYHDS-------------EIDMDQT 397

  Fly   462 AISLDEQD----ETSTSESSDSSKEKPAQTFATMTPK---EVSLWIDRKMRFVFPLSFIVFNALF 519
            ::||:.:|    ::..|.|:|||:.|..::......:   |.:..||...|.:||:.:|:||..:
Human   398 SLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFY 462

  Fly   520 W 520
            |
Human   463 W 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	114/456 (25%)
GABRR3	NP_001099050.1	LIC	55..466	CDD:273305	114/456 (25%)
		Neur_chan_LBD	59..267	CDD:280998	56/223 (25%)
		Neur_chan_memb	274..463	CDD:280999	54/222 (24%)
		Interaction with SQSTM1. /evidence=ECO:0000250	347..448		22/134 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810