Protein Alignment pHCl-2 and Gabrr3

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_620252.1
• Gene: Gabrr3 / 192258
• RGDID: 621564
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 428
• Identity: 115/428 - (26%)
• Similarity: 201/428 - (46%)
• Gaps: 49/428 - (11%)

  Fly    98 GEEVPMDIYARFYIYVMKNLDS---SDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELK 159
            |..||:.|..:     ::::||   .::.||:...|:..:.|.||:|.|   ...:.:..:..|.
  Rat    77 GSPVPVGIDVQ-----VESIDSISEVNMDFTMTFYLRHYWKDERLSFPS---TTNKSMTFDRRLI 133

  Fly   160 KMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTT 224
            :.:|||.||..:.:.|.:..|:.::.:..::|:|.||.|.|:..:..|:|:|.:||.|.|.|...
  Rat   134 QKIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCFMDFSRFPLDTQNCSLE 198

  Fly   225 LESWMYNTTLVQLHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISF 289
            |||:.||...:.|:|:..|     |.|...|:..:...:.|....|  |.::..|..|.|..:..
  Rat   199 LESYAYNEEDLMLYWKHGN-----KSLNTEEHISLSQFFIEEFSAS--SGLAFYSSTGWYYRLFI 256

  Fly   290 TVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKV 354
            ..:|.|.:.::|:..:.|::::|.:||||||:.....|||.:||.||:|:..|:......::.:|
  Rat   257 NFVLRRHIFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIVTGVSASMPQV 321

  Fly   355 SYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYR 419
            |||...:|:..|.::|:|.|::|:|.||.:                    |.|...|:..|.|..
  Rat   322 SYVKAVDVYMWVSSLFVFLSVIEYAAVNYL--------------------TTVEEWKQLNRRGKI 366

  Fly   420 RTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSS--KE 482
            .....:..:...:.| .|..:......:|...:.   |.|||.     :.:.:.|..:|||  |.
  Rat   367 SGMYNIDAVQAMAFD-GCYHDGETDVDQTSFFLH---SEEDSM-----RTKFTGSPCADSSQIKR 422

  Fly   483 KPAQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
            |...........|.:..||...|.|||:.:|:||..:|
  Rat   423 KSLGGNVGRIILENNHVIDTYSRIVFPVVYIIFNLFYW 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	115/428 (27%)
Gabrr3	NP_620252.1	LIC	58..463	CDD:455710	115/428 (27%)
		LGIC_ECD	79..264	CDD:475126	54/199 (27%)
		Interaction with SQSTM1. /evidence=ECO:0000269|PubMed:12431995	344..445		25/129 (19%)