Protein Alignment pHCl-2 and lgc-53

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_741945.3
• Gene: lgc-53 / 188702
• WormBaseID: WBGene00020657
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 457
• Identity: 119/457 - (26%)
• Similarity: 185/457 - (40%)
• Gaps: 115/457 - (25%)

  Fly   112 YVMKNLDSSD-----LQFTVQGLLQLR---------------YLDPRLAFS--SY------LPNR 148
            |...||.|::     ::.|||.:.::.               :.||||.||  :|      |.:.
 Worm    97 YDKNNLPSANSTEVIVELTVQSITEISEFSSSFKADVWFSQIWRDPRLDFSDRNYCLKNISLASH 161

  Fly   149 RQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQK 213
            :.|.|         |.|::...|.:...:..:.:::.|..|:|||||..:.|:..|..|.::...
 Worm   162 KLPTM---------WSPNVCFVNSKKVEIHASPSQNILLLIFPNGTVWLNFRVSLTGPCKLDLTY 217

  Fly   214 FPFDEQKCKTTLESWMYNTTLVQLHWETDNPVSF---DKQLQLTEYNLIGSLYNESIRVSNESYM 275
            ||.|.|.|....||:.|||..|::.|...:.|:.   |.: .|.::.|:      :|...|.:.:
 Worm   218 FPMDRQSCNLVFESYSYNTAEVRIVWRDWDAVTIPDPDSK-NLPDFELV------NIEHMNATLV 275

  Fly   276 SHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSF 340
            ....|..... :.||  ..|..||||:..::|:.:.|.|||::||:.....|||.|||.::|::.
 Worm   276 YTAGLWDQLE-VKFT--FRRLYGYYVLQAYMPTYLSVFISWIAFWIDTKALPARITLGVSSLMAL 337

  Fly   341 ITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKST 405
            .....:...||.:||||...::|...|..|||.||||.|.|.
 Worm   338 TFQFGNIVKNLPRVSYVKALDIWMFGCVGFIFLSLVELAVVG----------------------- 379

  Fly   406 FVPHLK-KHRRHG------YRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAI 463
            |...|: |.|||.      ..|:||....:|                         .||.:...:
 Worm   380 FADKLEAKRRRHNRCKEQLMMRSDSEQQWLS-------------------------RLSGQRPQV 419

  Fly   464 SLDEQDETSTSESSD--------SSKEKPAQTFATM-TPKEVS-LWIDRKMRFVFPLSFIVFNAL 518
            |....|.|.|.:.:|        .|:||..:....| :|..|: ..||.....:|||.|..||..
 Worm   420 SETNSDATHTIQINDGNGNVRRRKSEEKRQKLLLQMESPMFVNGEKIDEISAKLFPLLFTAFNIF 484

  Fly   519 FW 520
            :|
 Worm   485 YW 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	119/457 (26%)
lgc-53	NP_741945.3	LIC	87..489	CDD:455710	119/457 (26%)
		LGIC_ECD_GABAAR	108..292	CDD:349791	47/202 (23%)
		Cys-loop	211..225	CDD:349791	5/13 (38%)