Protein Alignment pHCl-2 and lgc-54

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001343648.1
• Gene: lgc-54 / 188525
• WormBaseID: WBGene00020528
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 440
• Identity: 118/440 - (26%)
• Similarity: 205/440 - (46%)
• Gaps: 45/440 - (10%)

  Fly    94 HNKDGEEVPMD-----IYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPI- 152
            :||:  .||:.     :...|.|..:..:......||:..|....:.||||.| .:|.|..|.:
 Worm    64 YNKN--TVPLKTSATVVSVEFGIQNIAQVSEISASFTLDLLFSQIWHDPRLRF-DHLTNCLQNLT 125

  Fly   153 MGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFD 217
            :|.|.::| ||.|::...|.:.:.:..:...:....|||||||..:.|||....|.::...||.|
 Worm   126 LGYSMVEK-LWTPNVCFVNSKKTEIHSSPTPNIFLMIYPNGTVWVNYRLQVQSPCMVDLVLFPMD 189

  Fly   218 EQKCKTTLESWMYNTTLVQLHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEG 282
            ...|:..:||:.||...|:|:|....||....:.:|:::.|.|..:.::         |.....|
 Worm   190 IMNCELIIESYAYNAAKVKLNWREWQPVFSIAKSKLSDFTLYGLQWTKN---------SFEYAAG 245

  Fly   283 NYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQ 347
            .:..::.::..:|..|:|::..::|:...|.:|:||||:.....|||.|||.::|::......:.
 Worm   246 QWDQLTVSLTFSRAYGFYILQMYIPTYSSVFLSFVSFWIDLKALPARITLGVSSLMALTFQYGNV 310

  Fly   348 ENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKK 412
            ..||.:|.||...:|:.::.|.|||.:::|.|||..:...|| |:.|:|..:...:...|...||
 Worm   311 AKNLPRVGYVKSIDVYMVLTTAFIFLTMIEVAFVCYLDSENN-LRRKERQAEKKKERVAVLQRKK 374

  Fly   413 HR-RHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSES 476
            .| ::.|..|..|.:..:.:.:..         ..:.|....|:.|.:   ||:..|     :.:
 Worm   375 DRKKNNYGATTVTNANAAESDLRS---------NYDEPFSQNGTTSHK---ISISRQ-----ANN 422

  Fly   477 SDSSKEKPAQTFATMT--PKEVSLW----IDRKMRFVFPLSFIVFNALFW 520
            ...|....|| |..:|  ..|.:.|    :|:..|..|||||...|.::|
 Worm   423 MFESLHALAQ-FGLLTDDDDENTKWTAQNVDKFCRKAFPLSFCFLNLIYW 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	118/440 (27%)
lgc-54	NP_001343648.1	LIC	55..474	CDD:455710	118/440 (27%)
		LGIC_ECD_GABAAR	76..258	CDD:349791	49/192 (26%)
		Cys-loop	179..193	CDD:349791	4/13 (31%)