Protein Alignment pHCl-2 and acc-2

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_501567.1
• Gene: acc-2 / 183758
• WormBaseID: WBGene00008280
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 488
• Identity: 114/488 - (23%)
• Similarity: 208/488 - (42%)
• Gaps: 78/488 - (15%)

  Fly    36 VVVSPLNTTD-AFSVSINLSQSTVNNCPSLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGE 99
            ::.:.|:.:: ..|..:..|.|.:::..:.|........:::.||.....|::...|       :
 Worm    13 IITTELDYSELVHSAELVSSSSYIHHKTNKKPDNCTRDTDIIDRLLNGTGYNKFRIP-------Q 70

  Fly   100 EVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWV 164
            |..|.:....:|..:.::|.....|.:...:...:|||.|.|.:..|.:....:....|.: ||.
 Worm    71 EEGMTVVVEIWIQAITSIDELTNDFDMDIYITETWLDPALNFQTMTPCKGNLSLNHQVLDR-LWT 134

  Fly   165 PHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWM 229
            |:....|.:.:.:..:..:.....::|||||:.:.|::....|.::...||.|.|||....||:.
 Worm   135 PNSCFINSKVAQIHNSPFRSVFLMLFPNGTVMVNYRVRVKGPCSLDLSNFPLDLQKCSLIYESFN 199

  Fly   230 YNTTLVQLHW-ETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLL 293
            ||...|::.| :.::||....::.|.:::    |:........|.|.:     |.:..:..|::.
 Worm   200 YNRQEVEMRWSDAEHPVFNLSKIMLPDFD----LFEIQTERRQEPYPA-----GMWDELHVTIIF 255

  Fly   294 TREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVT 358
            .|...:|.:..:||:.:.:.|||:||.|.:...||||.||..:||:.:....:...||.:|||:.
 Worm   256 ERRFIWYFMQAYLPTYLTIFISWISFSLGSRAIPARTMLGVNSLLAIVFSFGNIMRNLPRVSYIK 320

  Fly   359 MSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDS 423
            ..:||.||...|||.||:|.|.|.                 ::|:...|...|:.::
 Worm   321 GIDVWMLVSMTFIFCSLLELAIVG-----------------FMVRDETVAKKKQQKK-------- 360

  Fly   424 TMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAIS-LDEQDETSTSESSDSSKEKPAQT 487
                                        |.|::|||:|... :.|:........|:|||...:.|
 Worm   361 ----------------------------ISGNISREESPHGIISERRFMFPPGCSESSKSLSSCT 397

  Fly   488 FATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
             :..||:.    ||.....:||.||.|||.::|
 Worm   398 -SGWTPER----IDSISSVMFPFSFFVFNIIYW 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	113/477 (24%)
acc-2	NP_501567.1	LIC	52..428	CDD:455710	109/449 (24%)
		LGIC_ECD_GABAAR	76..258	CDD:349791	41/191 (21%)
		Cys-loop	177..191	CDD:349791	5/13 (38%)