Protein Alignment pHCl-2 and lgc-47

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_741878.1
• Gene: lgc-47 / 181193
• WormBaseID: WBGene00009799
• Length: 428
• Species: Caenorhabditis elegans
• Alignment Length: 436
• Identity: 97/436 - (22%)
• Similarity: 176/436 - (40%)
• Gaps: 93/436 - (21%)

  Fly    94 HNKDGEEVP-MDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMG--- 154
            :||.....| :|:....::..:.::......|.:...:...:.||.||:...     .|..|
 Worm    72 YNKHKLPSPQVDVRIEMWVQEVTSVSELTQDFEIDLYMNEYWTDPGLAYDIL-----NPCQGNLS 131

  Fly   155 -ESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDE 218
             :..:.:.:|.|:....|.:.:.:..:...:....::|||:|.::.|:::|..|.|:..|||.|.
 Worm   132 FDWAVMQNIWTPNTCFINSKKAQLHSSPFTNVFLMVFPNGSVWSNWRIKSTGPCVMDLTKFPMDS 196

  Fly   219 QKCKTTLESWMYNTTLVQLHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGN 283
            .:|..|.||:.||...|.:.| .|.|::..|.::|.::.:      .:...||:..:   ...|.
 Worm   197 IECTLTFESFNYNKDEVFMRW-GDPPLTIFKPIELPDFTM------TNFSTSNKFQL---YAAGY 251

  Fly   284 YSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQE 348
            :|.::...|..|..|:|::..::|:.|.|.|||:.|:|.....||||.:|...||:......:..
 Worm   252 WSELNVNFLFRRRSGWYLLQGYIPTYMTVFISWIPFYLGPKAIPARTMIGVNALLALTFQFGNII 316

  Fly   349 NNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKH 413
            .||.:|||:...:||.|....|:|.||.|.|.:..:.|...     |..||
 Worm   317 RNLPRVSYIKAIDVWMLSGICFVFASLFELATIGFLMRNEG-----KPATK-------------- 362

  Fly   414 RRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSD 478
                        |:.||.:.::...|               |:.|||:
 Worm   363 ------------SSRSTKNSNRWQQP---------------SVCREDT----------------- 383

  Fly   479 SSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFWTLVY 524
               ::.:|.......      :|...|.:||:.|..:|.::| .||
 Worm   384 ---QRKSQNIVFCER------LDNTSRLMFPVVFTFYNFIYW-FVY 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	95/432 (22%)
lgc-47	NP_741878.1	LGIC_ECD_GABAAR	82..264	CDD:349791	40/196 (20%)
		Cys-loop	185..199	CDD:349791	6/13 (46%)
		LGIC_TM_anion	267..416	CDD:349851	49/220 (22%)
		TM1 helix	267..290	CDD:349851	8/22 (36%)
		TM2 helix	294..318	CDD:349851	7/23 (30%)
		TM3 helix	326..391	CDD:349851	22/130 (17%)
		TM4 helix	392..416	CDD:349851	6/29 (21%)