Protein Alignment pHCl-2 and acc-4

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001379219.1
• Gene: acc-4 / 176778
• WormBaseID: WBGene00012099
• Length: 408
• Species: Caenorhabditis elegans
• Alignment Length: 476
• Identity: 113/476 - (23%)
• Similarity: 190/476 - (39%)
• Gaps: 114/476 - (23%)

  Fly    54 SQSTVNNCPSLKNAESMALMELLTRLTAPCRYDRMVPPVV---HNK----DGEEVPMDIYARFYI 111
            |...:.|||  |.|.::::..  |..|  |..|..:...:   :||    .|..|.:.|  ..::
 Worm    26 SNECMFNCP--KRARNVSVPH--TEKT--CMGDDAIIAQILDGYNKLDLPGGGHVVVSI--EIWV 82

  Fly   112 YVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQAST 176
            ..:..:.....:|.:...:..|:.||.||:|...|.:....:..:.:...:|.||....|.:.:.
 Worm    83 QEVSKIIEITSEFELDIYVTERWTDPSLAYSHLNPCKSNMSVDGATILNKIWNPHACFVNSKLAN 147

  Fly   177 VLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHW-E 240
            :..:..|:....||.||::..:.|::.|..|....:.||.|:|:|....||:.:||..|::.| .
 Worm   148 IHESPFKNIFLQIYSNGSIWHNYRIKLTGPCSSTLRTFPIDQQRCMLFYESFTHNTDQVKMEWIT 212

  Fly   241 TDNPVSFDK-QLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDY 304
            |..|::..| .:.|.:|.|:....:..:|:......       |..|.:||  ..|..|:|::..
 Worm   213 TVPPITILKGNITLPDYVLVDFSSSSELRLYPPGIF-------NELIATFT--FQRLYGFYILQV 268

  Fly   305 FLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTI 369
            ::|:.:.|.||||||.|.|:|.|:|||:|..:||:......:..|||.|.|.|...:||.|....
 Worm   269 YVPAYISVFISWVSFTLGAEQIPSRTTVGVNSLLALTFQFGAVVNNLPKTSDVKAIDVWILSSMA 333

  Fly   370 FIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMD 434
            |||.||:|.|.|.                          :|.:..:|
 Worm   334 FIFASLIELAVVG--------------------------YLSRDGQH------------------ 354

  Fly   435 KTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLW 499
                               ||:....|.:.::.:|.|                         :|.
 Worm   355 -------------------GSIKCRCSWLCMNCKDWT-------------------------ALK 375

  Fly   500 IDRKMRFVFPLSFIVFNALFW 520
            ||:....|||:||:.||..:|
 Worm   376 IDQMSSIVFPVSFLAFNIWYW 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	113/476 (24%)
acc-4	NP_001379219.1	LGIC_ECD_GABAAR	74..259	CDD:349791	44/195 (23%)
		LGIC_TM_anion	263..396	CDD:349851	53/220 (24%)
		TM1 helix	266..286	CDD:349851	8/19 (42%)
		TM2 helix	295..316	CDD:349851	6/20 (30%)
		TM3 helix	326..348	CDD:349851	11/47 (23%)
		TM4 helix	375..396	CDD:349851	9/20 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810