Protein Alignment pHCl-2 and gab-1

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_499661.2
• Gene: gab-1 / 176691
• WormBaseID: WBGene00001512
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 555
• Identity: 149/555 - (26%)
• Similarity: 243/555 - (43%)
• Gaps: 103/555 - (18%)

  Fly    33 NGSVVVSPLN--TTDAFSVS-INLSQSTVNNCPSLKNAESMALMELLTRLTAPCRYDRMVPPVVH 94
            ||:   .|.|  |:|..|.| .|.||:..:|..||       |.:||      ..||..:.| ..
 Worm    26 NGT---KPHNNSTSDQMSSSWSNRSQTMYSNASSL-------LSDLL------LDYDIRLRP-GF 73

  Fly    95 NKDGEEVPMDIYARFYIYVMKNLDS---SDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGES 156
            ..|...:.|||       ::.:.||   .|:.:|:...|...:.|.||.:|:.:|.....:.|
 Worm    74 GGDALLLTMDI-------IIASFDSISEVDMDYTLTMYLHQYWTDERLRWSNEIPIDEMTLSG-- 129

  Fly   157 ELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKC 221
            |..:.:|||..||.|::.|.:...:.::::..|..:|.|....||.:||.|.||.:.||.|.|.|
 Worm   130 EFSQNIWVPDTFLANDKHSYLHEVTERNKMLRINVDGKVAYGMRLTSTLSCSMNLRNFPLDSQNC 194

  Fly   222 KTTLESWMYNTTLVQLHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSI 286
            ...:||:.|.|:.|.:.|.....|...:|..:.::.:.|....:|| ||..:        |:|..
 Worm   195 TVEIESYGYTTSEVLMKWNYPLAVHGVEQADVPQFTITGFHTEDSI-VSTAT--------GSYQR 250

  Fly   287 ISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNL 351
            :|....|.|.|||::...:||.::||.:||||||:..:.|.||..||.||:|:..|:|.....:|
 Worm   251 LSLVFQLRRSVGYFIFQTYLPCVLIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRQSL 315

  Fly   352 MKVSYVTMSEVWFLVCTIFIFGSLVEFAFVN-TIWRR-----------------NNDLQLKKRTT 398
            .::|||...:::.::|.:|:|.:|:|:|.|| :.|.|                 ..|.:......
 Worm   316 PRISYVKSIDIYLVMCFVFVFAALLEYAAVNYSYWGRERGKGGGGNEWPVNGANKEDRESAVNVQ 380

  Fly   399 KYIVKSTF--VPHLKKHRRHGYRRTDSTMST------MSTTSMDK---------TCGPNNTV--- 443
            |::.....  ||..:..|........||.:|      ..:||..|         .|...||:
 Worm   381 KWVPSGLMDGVPQPQDRRVEALEEAMSTSNTAAQNNNFESTSKPKKRSSSPIPPLCRAGNTISEE 445

  Fly   444 ----------------------ITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQ 486
                                  :..:|..:.|.|.:|....::|...: .|..:|......:..:
 Worm   446 SESPDYPRYSTTSLKGARPHASLNHKTHHLKGRSSARAKRRMTLARMN-VSMKQSISGIGRRARK 509

  Fly   487 TFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFWT 521
            ...|:..::|:| ||:..|.|||:.|||||..:|:
 Worm   510 VIPTIRVRDVNL-IDKYSRVVFPVCFIVFNLFYWS 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	143/540 (26%)
gab-1	NP_499661.2	LIC	67..545	CDD:455710	130/498 (26%)