Protein Alignment pHCl-2 and lgc-46

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_497338.2
• Gene: lgc-46 / 175279
• WormBaseID: WBGene00022106
• Length: 508
• Species: Caenorhabditis elegans
• Alignment Length: 512
• Identity: 125/512 - (24%)
• Similarity: 211/512 - (41%)
• Gaps: 87/512 - (16%)

  Fly    60 NCPSLKNA---------ESMALMELLT-----RLTAPCRYDRMV-PPVVHNKDGEEVP---MDIY 106
            |.|||:..         |...|..::.     |.|..|..|..: ..::.|.:..::|   :|:.
 Worm    26 NSPSLRRLTRNYDWEVDEHGGLKPIINPAKVERATKNCANDSFILGTIMSNYNRHKIPGGQVDVE 90

  Fly   107 ARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTN 171
            ...::..:..:......|.:...:...:.||.|.::...|.:....:....|:| ||.|:....|
 Worm    91 VEVWVQEITTISDITSDFQLDIYIYETWYDPALNYAFMNPCKYNLSLNSVLLEK-LWTPNSCFIN 154

  Fly   172 EQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQ 236
            .:.:.:..:...:....||.||||.|:.||:....|.|:..|||||...|..|.||:.|||..|:
 Worm   155 SKTADIHKSPFPNIFLMIYANGTVWTNYRLKLQGPCIMDLTKFPFDNVTCSLTFESFNYNTDEVK 219

  Fly   237 LHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYV 301
            :.|..:.......:::|.:|.|:..   ..|| :.|.|.:     |.:..::.:....|..|:|:
 Worm   220 MDWSVNGVQKMRDKMELADYELVDI---HKIR-TTEEYPA-----GYWHELTMSFEFKRRAGWYI 275

  Fly   302 IDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLV 366
            :..:||:.:.:.|||:||.|.:...||||.||..:||:......:...||.:||||...:||.|.
 Worm   276 LQAYLPTYLTICISWISFALGSKAIPARTMLGVNSLLAMTFQFGNIIRNLPRVSYVKAIDVWMLS 340

  Fly   367 CTIFIFGSLVEFAFVNTIWRRNNDLQLK--KRTTKYIVKSTFVPHLKK-------HRRH------ 416
            |..|:|.||:|.|:|..:.|.......|  :.:.:...|....|.:::       |||.
 Worm   341 CMTFVFCSLLELAWVGYLSREEEPTSAKCLQPSAQVAPKPCHPPPVQQNANNSSVHRRQKQPKNE 405

  Fly   417 ------------------GYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAI 463
                              |:....:..:.|.:.|...:|.|.|.|                  .:
 Worm   406 EESALLSLRDNDYGYIPPGFGLNGNVANAMKSFSSSCSCEPTNVV------------------NL 452

  Fly   464 SLDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
            .|||.:...||.||..|:::..:..|..        ||....|:||..|::||..:|
 Worm   453 MLDEAETIPTSTSSSLSRKQRREILAHK--------IDSVSVFMFPFLFVLFNIAYW 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	125/512 (24%)
lgc-46	NP_497338.2	LIC	73..504	CDD:455710	115/465 (25%)
		LGIC_ECD_GABAAR	87..270	CDD:349791	45/192 (23%)
		Cys-loop	190..204	CDD:349791	7/13 (54%)