Protein Alignment pHCl-2 and lgc-34

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_493752.1
• Gene: lgc-34 / 173443
• WormBaseID: WBGene00020836
• Length: 390
• Species: Caenorhabditis elegans
• Alignment Length: 551
• Identity: 106/551 - (19%)
• Similarity: 187/551 - (33%)
• Gaps: 190/551 - (34%)

  Fly     1 MDTLGIFVLISYLGLSSA-AGVHLGDLQQNLAANGSVVVSPLNTTDAFSVSINLSQSTVNNCPSL 64
            |..:.:|:::..:|:.|| ...|    .:.|...|.:|...|:..|:.|           ..|..
 Worm     1 MRNIFLFLVLLSIGVCSAQKAFH----SRRLGTEGQIVGRILSEYDSSS-----------RPPVR 50

  Fly    65 KNAESMALMEL----LTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFT 125
            .:|::.|::.:    :.||            :.||.         ||...:|:.:....|.|::.
 Worm    51 DHADNSAILVITNIFINRL------------IWHNN---------YAEVDLYLRQQWQDSRLKYD 94

  Fly   126 V---QGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELT 187
            |   :|:.::|           ||..|:           :|.|..:.|:.:      ..:::|..
 Worm    95 VDTREGIDEIR-----------LPGNRK-----------IWEPDTYFTSGK------ELSRNEKN 131

  Fly   188 S----IYPNGTVLTSTRLQATL-YCWMNFQKFPFDEQKCKT-TLESWMYNTTLVQLHWETD---- 242
            |    :.|:|.:.:|.|:...| |.:...  |||...:..| .|.|:.|:...:...|...
 Worm   132 SKHIVVEPSGYIRSSERVLLELPYAYGTM--FPFTNSRQFTIKLGSYNYDIDDIVYLWANSPPLV 194

  Fly   243 NPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSI-----ISFTVLLTREVGYYVI 302
            ||:...:.|      |.|.|..|.        .|.|...|||::     |...|..:......::
 Worm   195 NPIEVSQDL------LKGDLTFEE--------ASAGDCVGNYTVGVYSCIDAHVYFSASTISGLM 245

  Fly   303 DYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLS----LSQENNLMKVSYVTMSEVW 363
            .:||||:.::..||:.||:....:..||   .:..:.|..|:    ..:|:     ||......|
 Worm   246 SWFLPSLFLLIGSWLHFWIHGSWSVPRT---ISAAVPFFILAAYYIFMRED-----SYTQAQGAW 302

  Fly   364 FLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTM 428
            ...|.:..|.|.||:..|.....|        |:.:|
 Worm   303 LAFCLVLTFFSFVEYFLVICCGGR--------RSIRY---------------------------- 331

  Fly   429 STTSMDKTCGPNNTVITIETPIIIGGSLSREDSAI-SLDEQDETSTSESSDSSKEKPAQTFATMT 492
                  ||.||                  :||..: :..|..|.:.:|...|.::...
 Worm   332 ------KTLGP------------------QEDHPMGAAKETVEVAYNEGCASFRDNNG------- 365

  Fly   493 PKEVSLWIDRKMRFVFPLSFIVFNALFWTLV 523
                   ||...|..||:..|||..:::..:
 Worm   366 -------IDVISRVAFPIVTIVFLIIYFIFI 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	95/502 (19%)
lgc-34	NP_493752.1	LIC	1..388	CDD:455710	106/548 (19%)
		LGIC_ECD_anion	58..237	CDD:349788	48/243 (20%)
		Cys-loop	155..169	CDD:349788	4/15 (27%)