DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-2 and glc-2

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_491470.1	Gene:	glc-2 / 172103	WormBaseID:	WBGene00001592	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	494	Identity:	132/494 - (26%)
Similarity:	213/494 - (43%)	Gaps:	81/494 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LNTTDAFSVSINLSQSTVNNCPSLKNAE-SM-ALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPM 103
            :.|..:||:.:.|..     .|.:.|.| || :..|:|..|..  .||..|.|...|...|.. :
Worm     1 MTTPSSFSILLLLLL-----MPVVTNGEYSMQSEQEILNALLK--NYDMRVRPPPANSSTEGA-V 57

  Fly   104 DIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSS---YLPNRRQPIMGESELKKMLWVP 165
            ::.....|.::..:|..::::::|...:.:::|||||:.:   |.|   ...:....:||.||:|
Worm    58 NVRVNIMIRMLSKIDVVNMEYSIQLTFREQWIDPRLAYENLGFYNP---PAFLTVPHVKKSLWIP 119

  Fly   166 HIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMY 230
            ..|...|:|:.......::....|||:|.:|.|:|:..|..|.|..|.:|.|.|.|...|.|:.:
Worm   120 DTFFPTEKAAHRHLIDMENMFLRIYPDGKILYSSRISLTSSCPMRLQLYPLDYQSCNFDLVSYAH 184

  Fly   231 NTTLVQLHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTR 295
            ....:...|:...||.....:.....|.|...|     .:|....||.: .|:|..:...:|..|
Worm   185 TMNDIMYEWDPSTPVQLKPGVGSDLPNFILKNY-----TTNADCTSHTN-TGSYGCLRMQLLFKR 243

  Fly   296 EVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMS 360
            :..||::..:.|:.|||.:||||||:....|..|..||.||||:..|:..:....|..||||.:.
Worm   244 QFSYYLVQLYAPTTMIVIVSWVSFWIDLHSTAGRVALGVTTLLTMTTMQSAINAKLPPVSYVKVV 308

  Fly   361 EVWFLVCTIFIFGSLVEFAFV---NTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTD 422
            :||...|..|:||:|:|:|||   :::  |.||...:|...|           .:.||......|
Worm   309 DVWLGACQTFVFGALLEYAFVSYQDSV--RQNDRSREKAARK-----------AQRRREKLEMVD 360

  Fly   423 STMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQT 487
            :.:.....     ||                                  .|.|:.::.::|..:.
Worm   361 AEVYQPPC-----TC----------------------------------HTFEARETFRDKVRRY 386

  Fly   488 FATMTPKEVSLWIDRKMRFVFPLSFIVFNALFWTLVYCL 526
            |.  .|..:...||...|||.||:|:.||.::|  |.||
Worm   387 FT--KPDYLPAKIDFYARFVVPLAFLAFNVIYW--VSCL 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	128/483 (27%)
glc-2	NP_491470.1	LIC	29..419	CDD:273305	120/457 (26%)
		Neur_chan_LBD	29..244	CDD:280998	56/226 (25%)
		Neur_chan_memb	252..417	CDD:280999	60/218 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910