Protein Alignment pHCl-2 and Glrb

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_036018791.1
• Gene: Glrb / 14658
• MGIID: 95751
• Length: 530
• Species: Mus musculus
• Alignment Length: 515
• Identity: 130/515 - (25%)
• Similarity: 231/515 - (44%)
• Gaps: 57/515 - (11%)

  Fly    43 TTDAFSVSINLSQSTVNNCP-SLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIY 106
            |:|:..:.:.....:....| .|......:...:|.||..  .||..:.|   |..|  :|:|:.
Mouse    36 TSDSELLGLQACHHSCQQSPEDLARVPPNSTSNILNRLLV--SYDPRIRP---NFKG--IPVDVV 93

  Fly   107 ARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTN 171
            ...:|....::..:.:.:.|...|:.::.||||...|.. .....:..:..:.|.||.|.:|..|
Mouse    94 VNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDF-RGSDALTVDPTMYKCLWKPDLFFAN 157

  Fly   172 EQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQ 236
            |:::.....:.::.|..|:.:|.||.|.||..||.|.::...||.|.|:||..|||:.|.|..::
Mouse   158 EKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLR 222

  Fly   237 LHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYV 301
            ..|::.:||..:| :.|.:::    :..|.|...|.:....|:  |.|:.:.....|.|:||:|:
Mouse   223 FIWQSGDPVQLEK-IALPQFD----IKKEDIEYGNCTKYYKGT--GYYTCVEVIFTLRRQVGFYM 280

  Fly   302 IDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLV 366
            :..:.|:::||.:||:|||:..|.:.||..||..::||..:...:....|.|||||...:||.:.
Mouse   281 MGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIA 345

  Fly   367 CTIFIFGSLVEFAFVNTIWRRNNDLQLKK---------------RTTKYIVKSTFVP-HLK---- 411
            |.:|.|.||||:|.|..:......::.:|               ...|..|..|..| |:.
Mouse   346 CLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNAAKKNTVNGTGTPVHISTLQE 410

  Fly   412 --------KHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLD-- 466
                    .::..|: .||:..:.:..|...|.|...:.:.:.:..|:  |||.|:....:.|
Mouse   411 LPMVCQQITYQLDGW-PTDTLTTQVGETRCKKVCTSKSDLRSNDFSIV--GSLPRDFELSNYDCY 472

  Fly   467 ----EQDETSTSESSDSSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFWTL 522
                |.:.......:.:.|..||:.......|.:.|:    .|.:||..|:.||.::|::
Mouse   473 GKPIEVNNGLGKPQAKNKKPPPAKPVIPTAAKRIDLY----ARALFPFCFLFFNVIYWSI 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	128/510 (25%)
Glrb	XP_036018791.1	LIC	64..529	CDD:455710	126/487 (26%)
		LGIC_ECD_GlyR_beta	89..275	CDD:349811	51/193 (26%)
		Cys-loop	193..207	CDD:349811	5/13 (38%)