Protein Alignment pHCl-2 and Gabrg2

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_032099.1
• Gene: Gabrg2 / 14406
• MGIID: 95623
• Length: 474
• Species: Mus musculus
• Alignment Length: 531
• Identity: 129/531 - (24%)
• Similarity: 219/531 - (41%)
• Gaps: 98/531 - (18%)

  Fly     3 TLGIFVLIS-YLGLSSAAGVHLGDLQQNLAANGSVVVSPLNTTDAFSVSINLSQSTVNNCPSLKN 66
            ||.|.:|:| |.|.:|...   .|..::.|:|.:.|::|.......:|.:|
Mouse    23 TLWILLLLSLYPGFTSQKS---DDDYEDYASNKTWVLTPKVPEGDVTVILN-------------- 70

  Fly    67 AESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQ 131
                .|:|         .||..:.|.:..|     |..|:...|:..:..:::.::::|:.....
Mouse    71 ----NLLE---------GYDNKLRPDIGVK-----PTLIHTDMYVNSIGPVNAINMEYTIDIFFA 117

  Fly   132 LRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVL 196
            ..:.|.||.|:|.:...|.    .|.:...:|:|..|..|.:.:.....:..:.:..|:.:|.||
Mouse   118 QTWYDRRLKFNSTIKVLRL----NSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL 178

  Fly   197 TSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDN-PVSFDKQLQLTEYNLIG 260
            .:.||.....|.:....||.||..|.....|:.|....:...|:..: .|...:..:|.:::.:|
Mouse   179 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVG 243

  Fly   261 SLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQ 325
             |.|.:..|...|        |:|.::|....|:|.:||:.|..::|..:||.:||||||:..|.
Mouse   244 -LRNTTEVVKTTS--------GDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA 299

  Fly   326 TPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNND 390
            .||||:||.||:|:..|||.....:|.||||||..:::..||.||:|.:|||:.
Mouse   300 VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYG----------- 353

  Fly   391 LQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGS 455
                  |..|     ||.:.|..:....::.:..:...|..:......|.:..|.:
Mouse   354 ------TLHY-----FVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQM--------- 398

  Fly   456 LSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLW-----------IDRKMRFVFP 509
                ::|..|.|:||....|..|.  :..|..|..........|           :|...|..||
Mouse   399 ----NNATHLQERDEEYGYECLDG--KDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFP 457

  Fly   510 LSFIVFNALFW 520
            .:|.:||.::|
Mouse   458 TAFCLFNLVYW 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	116/487 (24%)
Gabrg2	NP_032099.1	LIC	68..471	CDD:455710	115/483 (24%)
		LGIC_ECD_GABAAR_G	89..270	CDD:349801	40/193 (21%)
		Cys-loop	189..203	CDD:349801	5/13 (38%)