Protein Alignment pHCl-2 and Gabrd

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_006538609.2
• Gene: Gabrd / 14403
• MGIID: 95622
• Length: 483
• Species: Mus musculus
• Alignment Length: 431
• Identity: 112/431 - (25%)
• Similarity: 205/431 - (47%)
• Gaps: 61/431 - (14%)

  Fly   102 PMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMG-ESELKKMLWVP 165
            |:::.....:..:.::..:::::|:...|...:.|.||::     |.....:| :|.....||:|
Mouse    97 PVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSY-----NHTNETLGLDSRFVDKLWLP 156

  Fly   166 HIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMY 230
            ..|:.|.:::.....:.:::|..:.|:|.:|.|.|:.:|:.|.|:..|:|.|||:|...|||:.|
Mouse   157 DTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPLDEQECMLDLESYGY 221

  Fly   231 NTTLVQLHW-ETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLT 294
            ::..:..:| |....:....:|||.::.:      .|.|.:.|  :.:....|.:..:|....|.
Mouse   222 SSEDIVYYWSENQEQIHGLDRLQLAQFTI------TSYRFTTE--LMNFKSAGQFPRLSLHFQLR 278

  Fly   295 REVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTM 359
            |..|.|:|..::||:::|.:||||||:.....|||.:||.||:|:..||.:|..::|.:.|.:..
Mouse   279 RNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKA 343

  Fly   360 SEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDST 424
            .:|:|.:|.:|:|.:|||:||.:.    |.|.: |||..|  ||.|      |.|.....|....
Mouse   344 LDVYFWICYVFVFAALVEYAFAHF----NADYR-KKRKAK--VKVT------KPRAEMDVRNAIV 395

  Fly   425 MSTMSTTSMDKTCGPNNTVITIETPII-----IGGSLSREDSAISLDEQDETSTSESSDS---SK 481
            :.::|...:.:           |..|.     :.|:|.....::.::.:.|..:......   |:
Mouse   396 LFSLSAAGVSQ-----------ELAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRPGGPGGIRSR 449

  Fly   482 EKP--AQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
            .||  |.|            ||...|.|||.:|...|.::|
Mouse   450 LKPIDADT------------IDIYARAVFPAAFAAVNIIYW 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	112/431 (26%)
Gabrd	XP_006538609.2	LGIC_ECD	97..280	CDD:355788	44/195 (23%)
		Cys-loop	198..212	CDD:349787	7/13 (54%)
		LGIC_TM_GABAAR_delta	283..>371	CDD:349857	35/91 (38%)
		TM1 helix	286..306	CDD:349857	10/19 (53%)
		TM2 helix	315..336	CDD:349857	8/20 (40%)
		TM3 helix	346..368	CDD:349857	10/25 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900