DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pHCl-2 and Gabrb2

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001334243.1	Gene:	Gabrb2 / 14401	MGIID:	95620	Length:	512	Species:	Mus musculus

Alignment Length:	514	Identity:	130/514 - (25%)
Similarity:	233/514 - (45%)	Gaps:	88/514 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SLKNAESMALME-----LLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDL 122
            |:.:..:|:|::     ||.......|.|...|||....:.:...:|:.:..      |:|
Mouse    26 SVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEV------NMD---- 80

  Fly   123 QFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELT 187
             :|:....|..:.|.||:::....|    :..::.:...||||..:..|::.|.|.|.:.|:.:.
Mouse    81 -YTLTMYFQQAWRDKRLSYNVIPLN----LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMI 140

  Fly   188 SIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWE-TDNPVSFDKQL 251
            .::|:||||...|:..|..|.|:.:::|.|||.|...:||:.|.|..::.:|. .||.|:...::
Mouse   141 RLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKI 205

  Fly   252 QLTEYNLIG-SLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTIS 315
            :|.:::::. .|..:.:..|.          |:|..:|.:..|.|.:||:::..::|||:|..:|
Mouse   206 ELPQFSIVDYKLITKKVVFST----------GSYPRLSLSFKLKRNIGYFILQTYMPSILITILS 260

  Fly   316 WVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAF 380
            |||||:..|.:.||..||.||:|:..|::......|.|:.||...:::.:.|.:|:|.:|:|:|.
Mouse   261 WVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYAL 325

  Fly   381 VNTIWRRNNDLQLKKRTTKYI----------VKSTFVPHLKKHRRHGYRR----TDSTMSTMSTT 431
            ||.|:......:.||...|..          |...|...:|::... ||.    |.....|..||
Mouse   326 VNYIFFGRGPQRQKKAAEKAANANNEKMRLDVNKMFYKDIKQNGTQ-YRSLWDPTGDLSPTRRTT 389

  Fly   432 SMD---KTCGPNNTVI--TIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEK------PA 485
            :.|   .|..|:..::  |:|    |...::..::.:.|.  |..||..:.|:|..:      |.
Mouse   390 NYDFSLYTMDPHENILLSTLE----IKNEMATSEAVMGLG--DPRSTMLAYDASSIQYRKAGLPR 448

  Fly   486 QTFAT------MTPKEVSL------------------WIDRKMRFVFPLSFIVFNALFW 520
            .:|..      :..|:..|                  .|||..|..||:.|..||.::|
Mouse   449 HSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYW 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	130/514 (25%)
Gabrb2	NP_001334243.1	LIC	9..510	CDD:273305	130/514 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810