Protein Alignment pHCl-2 and Gabra3

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001344745.1
• Gene: Gabra3 / 14396
• MGIID: 95615
• Length: 523
• Species: Mus musculus
• Alignment Length: 462
• Identity: 130/462 - (28%)
• Similarity: 205/462 - (44%)
• Gaps: 90/462 - (19%)

  Fly    85 YDRMVPPVVHNKDGE---EVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLP 146
            ||..:.|.:    |:   ||..|||...:    ..:..:|:::|:....:..:.|.||.|..  |
Mouse   109 YDNRLRPGL----GDAVTEVKTDIYVTSF----GPVSDTDMEYTIDVFFRQTWHDERLKFDG--P 163

  Fly   147 NRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNF 211
            .:..|:  .:.|...:|.|..|..|.:.|.....:..::|..:..|||:|.:.||.....|.|:.
Mouse   164 MKILPL--NNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHL 226

  Fly   212 QKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPVSFD---KQLQLTEYNLIGSLY-NESIRVSNE 272
            :.||.|...|.....|:.|....|...|......|.:   ...:|.:|:|:|.:. .|.||.|.
Mouse   227 EDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSST- 290

  Fly   273 SYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTL 337
                     |.|.:::....|.|::||:||..:||.||.|.:|.|||||..:..||||..|.||:
Mouse   291 ---------GEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTV 346

  Fly   338 LSFITLSLSQENNLMKVSYVTMSEVWFL-VCTIFIFGSLVEFAFVNTIWRRN---------NDLQ 392
            |:..|||:|..|:|.||:|.|..: ||: ||..|:|.:|:|||.||...:|:         ..|:
Mouse   347 LTMTTLSISARNSLPKVAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALE 410

  Fly   393 LKKR---------TTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIET 448
            :||:         ||..||.:|:..:|.|         |:..||:|.::...:.....|.|
Mouse   411 MKKKTPAAPTKKNTTFNIVGTTYPINLAK---------DTEFSTISKSAAAPSASSTPTAI---- 462

  Fly   449 PIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSFI 513
                                    .|..:...::.||:   |.|...||. :|:..|.:||:.|.
Mouse   463 ------------------------ASPKATYVQDSPAE---TKTYNSVSK-VDKISRIIFPVLFA 499

  Fly   514 VFNALFW 520
            :||.::|
Mouse   500 IFNLVYW 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	130/462 (28%)
Gabra3	NP_001344745.1	LIC	100..509	CDD:455710	130/462 (28%)
		LGIC_ECD_GABAAR_A3	106..305	CDD:349837	52/217 (24%)
		Cys-loop	222..236	CDD:349837	5/13 (38%)