Protein Alignment pHCl-2 and Gabra4

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_542154.3
• Gene: Gabra4 / 140675
• RGDID: 621670
• Length: 552
• Species: Rattus norvegicus
• Alignment Length: 578
• Identity: 143/578 - (24%)
• Similarity: 235/578 - (40%)
• Gaps: 151/578 - (26%)

  Fly    57 TVNNCPS--LKNAESMALMELLTRLT---------------APCRYDRMVPPVVHNKDGE----- 99
            :|...|:  |.:..|:||:.:|...|               .|..:.|::..::...|..
  Rat     3 SVQKVPAIVLCSGVSLALLHVLCLATCLNESPGQNSKDEKLCPENFTRILDSLLDGYDNRLRPGF 67

  Fly   100 -----EVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELK 159
                 ||..|||...:    ..:...::::|:....:..::|.||.:.           |..|:.
  Rat    68 GGPVTEVKTDIYVTSF----GPVSDVEMEYTMDVFFRQTWIDKRLKYD-----------GPIEIL 117

  Fly   160 KM-------LWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFD 217
            ::       :|.|..|..|.:.|.....:|.::|..|..|||:|.:.||..:..|.|....||.|
  Rat   118 RLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMD 182

  Fly   218 EQKCKTTLESWMYNTTLVQLHWETDNP---VSFDKQ-LQLTEYNLIGSLYNESIRVSNESYMSHG 278
            ...|.....|:.|..:.:...| |..|   |...|: ..|.:|:|||.      .||:|:..
  Rat   183 GHACPLKFGSYAYPKSEMIYTW-TKGPEKSVEVPKESSSLVQYDLIGQ------TVSSETIK--- 237

  Fly   279 SLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITL 343
            |:.|.|.:::....|.|::||::|..::|.||.|.:|.||||:..:..||||..|.||:|:..||
  Rat   238 SITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTL 302

  Fly   344 SLSQENNLMKVSYVTMSEVWFL-VCTIFIFGSLVEFAFVNTIWRRNNDLQ-LKKRTTKYIVKSTF 406
            |:|..::|.||||.|..: ||: ||..|:|.:|:|||.||  :..|..:| .||:.:|...:...
  Rat   303 SISARHSLPKVSYATAMD-WFIAVCFAFVFSALIEFAAVN--YFTNIQMQKAKKKISKPPPEVPA 364

  Fly   407 VPHLK-KHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPI----IIGGSLSREDSAISLD 466
            .|.|| ||.....:.|.:.::....|         |.::..|:.:    .:|...|:..:|   .
  Rat   365 APVLKEKHTETSLQNTHANLNMRKRT---------NALVHSESDVNSRTEVGNHSSKTTAA---Q 417

  Fly   467 EQDETS-----TSESSDSSKEKPAQTFA------------------------------------- 489
            |..||:     .|..:..|:...|:|.:
  Rat   418 ESSETTPKAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSASARPAFGARLG 482

  Fly   490 --------TMTPKEVSLW---------------IDRKMRFVFPLSFIVFNALFWTLVY 524
                    |..|..||..               ||:..|.:||::|..||.::| :||
  Rat   483 RIKTTVNTTGVPGNVSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYW-VVY 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	141/574 (25%)
Gabra4	NP_542154.3	LIC	13..539	CDD:273305	138/566 (24%)
		Neur_chan_LBD	49..256	CDD:280998	53/231 (23%)
		Neur_chan_memb	263..536	CDD:280999	75/287 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..436		18/94 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..470		0/21 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	486..513		4/26 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900