Protein Alignment pHCl-2 and Rdl

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_316070.4
• Gene: Rdl / 1276697
• VectorBaseID: AGAMI1_011163
• Length: 555
• Species: Anopheles gambiae
• Alignment Length: 602
• Identity: 149/602 - (24%)
• Similarity: 240/602 - (39%)
• Gaps: 158/602 - (26%)

  Fly     3 TLGIFVLISYLGL---------------SSAAGVHLGDLQQNLAANGSVVVSPLNTTDAFSVSIN 52
            :||:.:|...|.|               .:..|..|||:  |::|          ..|:|||.
Mosquito    14 SLGVLILTLNLALFLPQTINRTPPYVLAGTGGGSMLGDV--NISA----------ILDSFSVG-- 64

  Fly    53 LSQSTVNNCPSLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNL 117
                                            ||:.|.|   |..|.  |:::....|:..:.::
Mosquito    65 --------------------------------YDKRVRP---NYGGP--PVEVGVTMYVLSISSV 92

  Fly   118 DSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQP----IMGESELKKMLWVPHIFLTNEQASTVL 178
            ....:.||:....:..:.|||||:      |::|    :...||..|.:|||..|..||:.|...
Mosquito    93 SEVLMDFTLDFYFRQFWTDPRLAY------RKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFH 151

  Fly   179 GTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETD- 242
            ..:..:|...|:.:|::..|.||..|..|.||.|.||.|.|.|...:||:.|....::..|:..
Mosquito   152 IATTSNEFIRIHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWKDGL 216

  Fly   243 NPVSFDKQLQLTEYNLIGSLYNES-IRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFL 306
            :.|....:::|.::.::|.....: |.::.          ||||.::..:...|.:|||:|..::
Mosquito   217 SSVGMSSEVELPQFRVLGHRQRATEINLTT----------GNYSRLACEIQFVRSMGYYLIQIYI 271

  Fly   307 PSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFI 371
            ||.:||.||||||||..:.||||..||.||:|:..||..|....|.|:|||...:|:...|.:.:
Mosquito   272 PSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMV 336

  Fly   372 FGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRR--------------------- 415
            |.||:|:|.|..:.:|   :|::|:....|.|   :...||.::
Mosquito   337 FASLLEYATVGYMAKR---IQMRKQRFMAIQK---IAEQKKQQQADANHPPPPPPVASDHSHGHG 395

  Fly   416 HGYRRT------------DSTMSTMSTTSMDKTC---GP--NNTVITIETPII--IGGSLSREDS 461
            ||:..|            ..||..:......:.|   ||  ......:..|..  .||:|....:
Mosquito   396 HGHSHTHQHTPKQQMGSRSGTMQNVPPNMGSRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTIN 460

  Fly   462 AISLDEQ-------------------DETSTSESSDSSKEKPAQTFATMTPKEVSLWIDRKMRFV 507
            ......|                   ||.|.:........|.......:||.:    ||:..|.|
Mosquito   461 GGRGGGQPGGGGPPPGGPPGGGGGGPDEESAAPQHLIHPGKDINKLLGITPSD----IDKYSRIV 521

  Fly   508 FPLSFIVFNALFWTLVY 524
            ||:.|:.||.::| ::|
Mosquito   522 FPVCFVCFNLMYW-IIY 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	136/540 (25%)
Rdl	XP_316070.4	LIC	56..537	CDD:455710	138/556 (25%)
		LGIC_ECD_GABAR_RDL-like	78..261	CDD:349809	48/198 (24%)
		Cys-loop	180..194	CDD:349809	8/13 (62%)