Protein Alignment pHCl-2 and pHCl-1

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_061508178.1
• Gene: pHCl-1 / 1276287
• VectorBaseID: AGAMI1_005729
• Length: 883
• Species: Anopheles gambiae
• Alignment Length: 658
• Identity: 148/658 - (22%)
• Similarity: 253/658 - (38%)
• Gaps: 171/658 - (25%)

  Fly    22 HLGDLQQNLAANGS---------VVVSPLNTTDAFSVSINLSQSTVNNCPS---------LKNAE 68
            |...:|:::||:.:         :|...|....|.||.:.|...|:....|         ::.||
Mosquito   231 HAPSVQRDVAASPTTSRPASSHHLVRHSLCLYAASSVLLALCYLTIPTVASDTAHPIRGRVRFAE 295

  Fly    69 SMALMELLTRLTAPCRYD-RMVPPV--------VHNKD-GEEVP-------------MDIYARFY 110
            ..:..|:|..|....||| |::|||        :|..: .:.:|             :.:.....
Mosquito   296 GKSDKEILDHLLKNSRYDKRLLPPVDDADFCCGMHTPEMAKHIPDMRVPGRPQNRGTLTVNVSVL 360

  Fly   111 IYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQ-PIMGESELKKMLWVPHIFLTNEQA 174
            :..:.:.|.|.|::.|:.|||.::.||||.::    |:.| ..:......:.:|:|..:.
Mosquito   361 LLSLASPDESSLKYEVEFLLQQQWFDPRLRYA----NQSQYEYLNAIHHHEDIWLPDTYF----- 416

  Fly   175 STVLGTSAKDEL------TSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTT 233
              ::....||.:      ..||.|||:....|....|.|......||||:..|...|||..|..:
Mosquito   417 --IMHGDFKDPIIPMHFALRIYRNGTINYLMRRHLILSCQGRLNIFPFDDPLCSFALESISYEQS 479

  Fly   234 LVQLHWETDNPVSFDKQLQLTEYN--LIGS------------LYNESIRVSNESYMSH-----GS 279
            .:...|:.|.. :..|...||..|  ||.:            ...:::.|.:|.::.:     ..
Mosquito   480 AITYVWKNDED-TLRKSPSLTTLNAYLIQNQTIACPIKASWRAEGQTLSVEDEEFLCNLCQRRFE 543

  Fly   280 LEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLS 344
            .:||||.:...::.||:..:|....|:|.|::||.|:::|||:.:..|||:.:|.||:|:|.|.|
Mosquito   544 EQGNYSCLKVDLIFTRDRAFYFTTVFIPGIILVTSSFITFWLEWNAVPARSMIGVTTMLNFFTTS 608

  Fly   345 LSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWR---------RNNDLQLKKRTTKY 400
            ....:.|..||.:|...||..||..||:.||:||..||.:.|         |..:..:.:|....
Mosquito   609 NGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAV 673

  Fly   401 I----------VKSTFVPHLKKHRRH----GYRRTDSTMST--------MSTTSMDKTCGPNNTV 443
            :          :.|..:|.......|    ..:.|.:|.::        ::.|...:|..|..||
Mosquito   674 LSRIGIILASPLSSRLLPETIDREFHTAIAAEKTTPATAASVAAATAGRLAQTPPHRTVAPAATV 738

  Fly   444 ITIET-PIIIGGSLSREDSAISLDEQ------------------------DETSTSESSDSSKEK 483
            ..:.| ||....:.:...:|:.|.|:                        :|....|:|...|::
Mosquito   739 PPLATAPIAPPIASAAPAAAVLLCEEGLATDASSAGPGLTRRRPTVETKLNEAGLMETSFGVKKR 803

  Fly   484 PA------------------------QTFATMT------------PKEVSLWIDRKMRFVFPLSF 512
            .:                        ...||.|            |..|:..||...|..||.::
Mosquito   804 ESGGPNEIVACTSCAGGTSPCTHSANNGCATETCFVQVRKKEPPHPIRVAKTIDVIARITFPSAY 868

  Fly   513 IVFNALFW 520
            .||...|:
Mosquito   869 AVFLIFFF 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	142/625 (23%)
pHCl-1	XP_061508178.1	None