Protein Alignment pHCl-2 and Gabra5

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_795916.1
• Gene: Gabra5 / 110886
• MGIID: 95617
• Length: 463
• Species: Mus musculus
• Alignment Length: 444
• Identity: 131/444 - (29%)
• Similarity: 206/444 - (46%)
• Gaps: 65/444 - (14%)

  Fly    85 YDRMVPPVVHNKDGE---EVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLP 146
            ||..:.|.:    ||   :|..|||...:    ..:..:::::|:....:..:.|.||.|..  |
Mouse    60 YDNRLRPGL----GERITQVRTDIYVTSF----GPVSDTEMEYTIDVFFRQSWKDERLRFKG--P 114

  Fly   147 NRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNF 211
            .:|.|:  .:.|...:|.|..|..|.:.|.....:..::|..:..:||:|.:.||..:..|.|..
Mouse   115 MQRLPL--NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQL 177

  Fly   212 QKFPFDEQKCKTTLESWMYNTTLVQLHW---ETDNPVSFDKQLQLTEYNLIG-SLYNESIRVSNE 272
            :.||.|...|.....|:.|..:.|...|   .|.:.|..:...:|.:|:|:| ::..|:|..|.
Mouse   178 EDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTST- 241

  Fly   273 SYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTL 337
                     |.|:|::....|.|::||:||..:||.||.|.:|.|||||..:..||||..|.||:
Mouse   242 ---------GEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTV 297

  Fly   338 LSFITLSLSQENNLMKVSYVTMSEVWFL-VCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYI 401
            |:..|||:|..|:|.||:|.|..: ||: ||..|:|.:|:|||.||...:|......||......
Mouse   298 LTMTTLSISARNSLPKVAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAK 361

  Fly   402 VKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLD 466
            :|       ||.|.....:     ||.:.|:...|..||   |..|.|  ..|:.:....:|...
Mouse   362 IK-------KKERELILNK-----STNAFTTGKLTHPPN---IPKEQP--PAGTANAPTVSIKAS 409

  Fly   467 EQDETSTSESSDSSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
            | ::|:.|:.:.:|..|                ||:..|.|||:.|..||.::|
Mouse   410 E-EKTAESKKTYNSISK----------------IDKMSRIVFPILFGTFNLVYW 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	131/444 (30%)
Gabra5	NP_795916.1	LIC	15..449	CDD:455710	131/444 (30%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	52/217 (24%)
		Cys-loop	173..187	CDD:349839	5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..408		7/25 (28%)