Protein Alignment pHCl-2 and gabra1

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_031754594.1
• Gene: gabra1 / 100490334
• XenbaseID: XB-GENE-6033338
• Length: 454
• Species: Xenopus tropicalis
• Alignment Length: 508
• Identity: 132/508 - (25%)
• Similarity: 213/508 - (41%)
• Gaps: 116/508 - (22%)

  Fly    46 AFSVSINLS------QSTVNNCPSLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGE---EV 101
            |:::.:||:      |||.:   .:|: .:.....:|.||..  .||..:.|.:    ||   ||
 Frog    13 AWTIMLNLTSEISCGQSTQD---EIKD-NTTIFTRILDRLLD--GYDNRLRPGL----GERVTEV 67

  Fly   102 PMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPH 166
            ..||:...:    ..:...|:::|:....:..:.|.||.|...:...|.    .:.:...:|.|.
 Frog    68 NTDIFVTSF----GPVSDHDMEYTIDVFFRQGWRDERLKFKGPMTVLRL----NNLMASKIWTPD 124

  Fly   167 IFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYN 231
            .|..|.:.|.....:..::|..|..:||:|.:.||.....|.|:.:.||.|...|.....|:.|.
 Frog   125 TFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYT 189

  Fly   232 TTLVQLHWETDNPVSF---DKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLL 293
            ...|...|..:..:|.   :...:|.:|:|:|......|..|:         .|.|.:::....|
 Frog   190 RAEVVYSWTREPSLSVVVAEDGSRLNQYDLLGQTVASGIVQSS---------TGEYIVMTTHFHL 245

  Fly   294 TREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVT 358
            .|::||:||..:||.||.|.:|.|||||..:..||||..|.||:|:..|||:|..|:|.||:|.|
 Frog   246 KRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYAT 310

  Fly   359 MSEVWFL-VCTIFIFGSLVEFAFVNTIWRRN----------------NDLQLKKRTTKYIVKSTF 406
            ..: ||: ||..|:|.:|:|||.||...:|.                .|..:||..|.....:.:
 Frog   311 AMD-WFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYASATANY 374

  Fly   407 VPHLKKHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDET 471
            .|.:.:         |..::|::                                        ::
 Frog   375 PPTIPR---------DPGLATIA----------------------------------------KS 390

  Fly   472 STSESSD-SSKEKPAQ---TFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
            :|.|..| ..|.|||:   ||.:::.      |||..|..|||.|..||.::|
 Frog   391 ATIEPKDIEPKPKPAEPKKTFNSVSK------IDRLSRIAFPLLFGTFNLVYW 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	132/508 (26%)
gabra1	XP_031754594.1	LIC	11..440	CDD:455710	132/508 (26%)
		LGIC_ECD_GABAAR_A1	55..248	CDD:349835	46/213 (22%)
		Cys-loop	165..179	CDD:349835	5/13 (38%)