DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-2 and gabrb1

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_002664179.2	Gene:	gabrb1 / 100331377	ZFINID:	ZDB-GENE-090313-230	Length:	484	Species:	Danio rerio

Alignment Length:	518	Identity:	127/518 - (24%)
Similarity:	228/518 - (44%)	Gaps:	107/518 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VSINLSQS----TVNNCPSLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARF 109
            |::.|.:|    :||. ||..:...:.:.:||.......|.|...|||           |:....
Zfish    23 VALTLGRSPPAHSVNE-PSNMSYVKVTVDKLLKGYDIRLRPDFGGPPV-----------DVGMSI 75

  Fly   110 YIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQA 174
            .|..:..:...::.:|:....|..:.|.||:::....|    :..::.:...||||..:..|::.
Zfish    76 DISSIDMVSEVNMDYTITMYFQQSWRDKRLSYTGIPLN----LTLDNRVADQLWVPDTYFINDKK 136

  Fly   175 STVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHW 239
            |.|.|.:.|:.:..::|:||||...|:..|..|.|:.:::|.|||.|...:||:.|.|..::.:|
Zfish   137 SFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW 201

  Fly   240 ETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDY 304
            :..:.|:....::|.::::|     :...:|.:...:.||    |..:|.:..|.|.:||:::..
Zfish   202 QGGSSVTGVDNIELPQFSII-----DYKTLSKKVVFATGS----YPRLSLSFKLKRNIGYFILQT 257

  Fly   305 FLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTI 369
            ::||.:|..:||||||:..|.:.||..||.||:|:..|::......|.|:.||...:::.:.|.:
Zfish   258 YMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDIYLMGCFV 322

  Fly   370 FIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMD 434
            |:|.:|:|:||||.|:....                  |||:|                  ...:
Zfish   323 FVFLALLEYAFVNYIFFGRG------------------PHLQK------------------KVAE 351

  Fly   435 KTCGPNNTVITIET---PIIIGGS--LSREDSAISLDEQ-----DETSTSESSDSSK---EKP-- 484
            |....||....:|:   .:.:.||  |:..|..:|..|.     |..:|..|.||:.   .||
Zfish   352 KAAKSNNEKSRLESNKVQVDVHGSIPLTNLDLRLSGAEMLGALGDPRNTMFSYDSASIQYRKPLT 416

  Fly   485 ---------AQTFATMTPKEVSL------------------WIDRKMRFVFPLSFIVFNALFW 520
                     |.....:.||:..|                  .||:..|.:||:::..||.::|
Zfish   417 GRDLYGRPTASIERPLAPKKSRLRRRAAQLKVKIPDLTDVNAIDKWSRVIFPITYTFFNLVYW 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	127/518 (25%)
gabrb1	XP_002664179.2	LIC	19..482	CDD:273305	127/518 (25%)
		Neur_chan_LBD	49..250	CDD:280998	53/224 (24%)
		Neur_chan_memb	257..479	CDD:280999	64/257 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810