DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-2 and LOC100330554

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_002662272.3	Gene:	LOC100330554 / 100330554	-ID:	-	Length:	475	Species:	Danio rerio

Alignment Length:	548	Identity:	133/548 - (24%)
Similarity:	245/548 - (44%)	Gaps:	103/548 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTLGIFVLISYLGLSSAA----GVHLGDLQQNLAANGSVVV--------SPLNTTDAFSVSINL 53
            |:|:.:|..:..||:|..:    |..|...:|:.....:..|        ||:     |..|.::
Zfish     3 METVLVFFCVGLLGVSGRSAPKPGQKLETYKQSRLRRETTRVDGGNHKSGSPI-----FRRSPDM 62

  Fly    54 SQSTVNNCPSLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLD 118
            ::|     |..|:.:.:.:.:          :|..:.|..   .|..:|:.:..:  :..:..:.
Zfish    63 TKS-----PMTKSEQLLRIDD----------HDFTMRPAF---GGPPIPVGVDVQ--VESLDTIS 107

  Fly   119 SSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAK 183
            ..|:.||:...|:..:.|.||:|.|   ...|.:..:|.|.|.:|||.:|..:.:.|.:..|:..
Zfish   108 EVDMDFTMTLYLRHYWKDERLSFPS---TNNQSMTFDSRLVKKIWVPDMFFVHSKRSFIHDTTTD 169

  Fly   184 DELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDN-PVSF 247
            :.:..:||:|.||.|.|:..|..|.|:..:||.|.|.|...:||:.|....:.|:|:..| .::.
Zfish   170 NVMLRVYPDGNVLYSLRVTVTAMCNMDLSRFPLDTQTCSLEIESYAYTDDDLMLYWKKGNESLNT 234

  Fly   248 DKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIV 312
            |.::.|:::.:  ..::.:.:::  .|.|.|.....|  |.||  |.|.|.::::..:.|:.::|
Zfish   235 DDRISLSQFFI--QKFHTTTKLA--FYSSTGWYNRLY--IHFT--LRRHVFFFLLQTYFPATLMV 291

  Fly   313 TISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVE 377
            .:||||||:.....|||..||.||:|:..|:......::.:|||:...:::..|..:|:|.|::|
Zfish   292 MLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVIE 356

  Fly   378 FAFVNTIW----RRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMDKTCG 438
            :|.||.:.    ||...|:.:...|..|....               .|..|:|..:.....|.|
Zfish   357 YAAVNYLTTVQERRERKLRNQLPCTCGIANPD---------------EDMMMTTCYSDVDPNTTG 406

  Fly   439 ----PNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLW 499
                |.|           ||...|..:.:||           |||.:....:|    |...|::|
Zfish   407 TYGLPEN-----------GGRQERILAQLSL-----------SDSQRNSRVKT----TRGYVNIW 445

  Fly   500 -----IDRKMRFVFPLSFIVFNALFWTL 522
                 ||:..|.:||.::.:||.::|::
Zfish   446 IDTHAIDKYSRVIFPAAYSLFNIVYWSI 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	121/489 (25%)
LOC100330554	XP_002662272.3	LIC	70..474	CDD:273305	116/471 (25%)
		Neur_chan_LBD	71..276	CDD:280998	55/230 (24%)
		Neur_chan_memb	283..471	CDD:280999	59/228 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910