Protein Alignment pHCl-2 and gabra2

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_002933509.2
• Gene: gabra2 / 100170583
• XenbaseID: XB-GENE-1000398
• Length: 451
• Species: Xenopus tropicalis
• Alignment Length: 456
• Identity: 127/456 - (27%)
• Similarity: 200/456 - (43%)
• Gaps: 95/456 - (20%)

  Fly    85 YDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRR 149
            ||..:.|.:    |:.| .:::...|:.....:..:|:::|:....:..:.|.||.|...:...|
 Frog    54 YDNRLRPGL----GDRV-TEVHTDIYVTSFGPVSDTDMEYTIDVFFRQNWQDERLRFKGPMHILR 113

  Fly   150 QPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKF 214
            .    .:.:...:|.|..|..|.:.|.....:..::|..|..:||:|.:.||.....|.|:.:.|
 Frog   114 L----NNLMANKIWTPDTFFHNGKKSIAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDF 174

  Fly   215 PFDEQKCKTTLESWMYNTTLVQLHW---ETDNPVSFDKQLQLTEYNLIGSLY-NESIRVSNESYM 275
            |.|...|.....|:.|.|:.|...|   .|::.|......:|.:|.|:|.|. .|:|:.|.
 Frog   175 PMDAHACPLKFGSYAYTTSEVTYVWTRNATESVVVAPDGSRLNQYVLLGHLVGKETIKSST---- 235

  Fly   276 SHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSF 340
                  |.|::::....|.|::||:||..:||.||.|.:|.|||||..:..||||..|.||:|:.
 Frog   236 ------GEYTVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM 294

  Fly   341 ITLSLSQENNLMKVSYVTMSEVWFL-VCTIFIFGSLVEFAFVNTIWRRN---------NDLQ--- 392
            .|||:|..|:|.||:|.|..: ||: ||..|:|.:|:|||.||...:|.         ||.:
 Frog   295 TTLSISARNSLPKVAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEK 358

  Fly   393 ---LKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGG 454
               :||.....:..:.:.|::.|         ||.:.|:
 Frog   359 ASVIKKNNAYAVAVANYAPNITK---------DSALPTI-------------------------- 388

  Fly   455 SLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALF 519
                             |.|.::|.:|.||.:  |..|...||. |||..|.||||.|..||.::
 Frog   389 -----------------SKSATADPNKAKPQE--AKKTFNSVSK-IDRMSRIVFPLLFGTFNLVY 433

  Fly   520 W 520
            |
 Frog   434 W 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	127/456 (28%)
gabra2	XP_002933509.2	LIC	12..437	CDD:455710	127/456 (28%)
		LGIC_ECD_GABAAR_A2	48..250	CDD:349836	49/214 (23%)
		Cys-loop	167..181	CDD:349836	5/13 (38%)