Protein Alignment ppk24 and ASIC3

DIOPT Version :9

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 122/599 - (20%)
• Similarity: 194/599 - (32%)
• Gaps: 221/599 - (36%)

  Fly    31 ARYP--PIRTLAPN-------HLPGTSAEDTRKLSFAAALKDLLQNLSFHCYSKLVESGRRIQER 86
            ||.|  .||..|.|       |:.|..:...|:..:|||:  :|...:|     |.:...|:  |
Human    10 ARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAV--VLSVATF-----LYQVAERV--R 65

  Fly    87 FFWFVFHITALTVLIAFLWGTYTKEQEALVTTMYHPMYPIWKVEFPAISVCSLN-----RISQRA 146
            ::....|.|||.          .:|...|:              |||:::|::|     |::...
Human    66 YYREFHHQTALD----------ERESHRLI--------------FPAVTLCNINPLRRSRLTPND 106

  Fly   147 AWQYAHNLSGKDPKQRNASHFYDQL------KAFMYMYYDPSDLMDIDNALRFQSFLDRFDTAKE 205
            .......|.|.||.:..|  |...|      ..||     ||...|:                 .
Human   107 LHWAGSALLGLDPAEHAA--FLRALGRPPAPPGFM-----PSPTFDM-----------------A 147

  Fly   206 ELFFNTRNRMSALTPNCSDMFVSCRIAGRLFDC-MDKFETTLTSHGFCCTFNYDGRYVNKRDFRQ 269
            :|:....:.:       .||.:.||..|:  .| .:.|.|..|..|.|.|||
Human   148 QLYARAGHSL-------DDMLLDCRFRGQ--PCGPENFTTIFTRMGKCYTFN------------- 190

  Fly   270 RYFGPD-----------MGLVLTLKTDPSDNFYKINGHNGYPDPFSGGVAERV------------ 311
              .|.|           ||..|.:..|.....|.....:....||..|:..::
Human   191 --SGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQL 253

  Fly   312 ---AETGFNTLLPVRAKIFETLP------EARSMSPSVRKCLFENE----------MPWIFARHY 357
               ...|:.|.:..:.:....||      .:.|::|:     :|.|          .|   :..|
Human   254 GLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPN-----YEPEPSDPLGSPSPSP---SPPY 310

  Fly   358 TFSKCISACRAQSVVSLCEC--------VPFSLPHRYIDGSEKRIYCTLQHLACLKRYEFKWLNV 414
            |...|..||..:.|...|.|        ||...|.:|.:.:...|...|:
Human   311 TLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR--------------- 360

  Fly   415 ITSRENVTGLEHELQDALYCPLCLASCTETRYSVRGAMTLGLPTPSQIKGPARSNPGPRANNSYG 479
                          :|:..||   ..|..|||:...:|         ::.|:|
Human   361 --------------KDSCACP---NPCASTRYAKELSM---------VRIPSR------------ 387

  Fly   480 PASSSGSAKGPVHSSSAPAE-LAVVRIYFAETHIQYFRQIIKSAWYETFSTIGNI---CGIIAGF 540
             |::...|:....|.:..|| :..:.|:|...:.:...|  |.| ||....:|:|   .|:..|.
Human   388 -AAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQ--KKA-YEMSELLGDIGGQMGLFIGA 448

  Fly   541 SLIGICELLFFLAK 554
            ||:.|.|:|.:|.:
Human   449 SLLTILEILDYLCE 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	108/551 (20%)
ASIC3	NP_064717.1	ASC	20..534	CDD:295594	117/589 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		5/29 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152105
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850