DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk24 and Asic1

DIOPT Version :9

Sequence 1:	NP_651860.2	Gene:	ppk24 / 43702	FlyBaseID:	FBgn0039839	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_006257440.1	Gene:	Asic1 / 79123	RGDID:	71062	Length:	559	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	110/545 - (20%)
Similarity:	173/545 - (31%)	Gaps:	179/545 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 KDLL---QNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFLWGTYTKEQEALVTTMYHPM 123
            :||:   .:.:.|..|.:...|.....:..|.|..:.||.   |||.....:       ..|:..
  Rat    61 RDLVAFANSCTLHGASHVFVEGGPGPRQALWAVAFVIALG---AFLCQVGDR-------VAYYLS 115

  Fly   124 YP---------IWKVEFPAISVCSLN--RISQRAAWQYAHNLSGKDPKQRNASHFYDQLKAFMYM 177
            ||         ..::.|||::.|:.|  |:||.:                    :.|.|.....:
  Rat   116 YPHVTLLDEVATTELVFPAVTFCNTNAVRLSQLS--------------------YPDLLYLAPML 160

  Fly   178 YYDPSDLMDIDNALRFQSFLDRFDTAKEELF----FNTRNRMSALTPNCSDMFVSCRIAGRLFDC 238
            ..|.||...:..|           ....|.|    ||.....:.......||.:.|...|.  .|
  Rat   161 GLDESDDPGVPLA-----------PPGPEAFSGEPFNLHRFYNRSCHRLEDMLLYCSYCGG--PC 212

  Fly   239 -MDKFETTLTSHGFCCTFN--YDGRYVNKR-------------DFRQRYFGPDMGLVLTLKTDPS 287
             ...|....|.:|.|.|||  .|||...|.             |.:|..:.|..|     :||.:
  Rat   213 GPHNFSVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWG-----ETDET 272

  Fly   288 --DNFYKINGHNGYPDPFSGGVAERVAETGFNTLLPVRAKIFETLPEARSMSPSVRKCLFENEMP 350
              :...|:..|:....||...:...|| .||.|.:..:.:....||.                 |
  Rat   273 SFEAGIKVQIHSQDEPPFIDQLGFGVA-PGFQTFVSCQEQRLIYLPS-----------------P 319

  Fly   351 W----------IFARHYTFSKCISACRAQSVVSLCEC--------VPFSLPHRYIDGSEKRIYCT 397
            |          .|...|:.:.|...|..:.:|..|.|        .|:..|.:|.:.::..:...
  Rat   320 WGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFL 384

  Fly   398 LQHLACLKRYEFKWLNVITSRENVTGLEHELQDALYCPLCLASCTETRYSVRGAMTLGLPTPSQI 462
            ::                             :|..|| :|...|..|||....:|         :
  Rat   385 VE-----------------------------KDQEYC-VCEMPCNLTRYGKELSM---------V 410

  Fly   463 KGPARSNPGPRANNSYGPASSSGSAKGPVHSSSAPAE-LAVVRIYFAETHIQYFRQIIKSAWYET 526
            |.|::             ||:...||....|.....| :.|:.|:|...:.:...|  |.| ||.
  Rat   411 KIPSK-------------ASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQ--KKA-YEI 459

  Fly   527 FSTIGNI---CGIIAGFSLIGICEL 548
            ...:|:|   .|:..|.|::.:.||
  Rat   460 AGLLGDIGGQMGLFIGASILTVLEL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	108/542 (20%)
Asic1	XP_006257440.1	ASC	63..541	CDD:295594	109/543 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345604
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950