Protein Alignment ppk24 and Asic4

DIOPT Version :10

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_071570.2
• Gene: Asic4 / 63882
• RGDID: 621068
• Length: 539
• Species: Rattus norvegicus
• Alignment Length: 586
• Identity: 123/586 - (20%)
• Similarity: 186/586 - (31%)
• Gaps: 204/586 - (34%)

  Fly    59 AALKDL---LQNLSFHCYSKLVESGRRIQERFFWFVFHITALTVLIAFLWGTYTKEQEALVTTMY 120
            ||.:||   ....:.|...:....|.....|..|.   :..||.|.|||:      |.|.:...|
  Rat    37 AAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWV---LALLTSLAAFLY------QAASLARGY 92

  Fly   121 ---------HPMYPIWKVEFPAISVCSLNRISQRAAWQ----YAHNLSGKDPKQRNASHFYDQLK 172
                     .|..|.....|||:::|::||....|...    :..||:|..||.|      |..:
  Rat    93 LTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDR------DGHR 151

  Fly   173 AFMYMYYDPSDLMDIDNALRFQSFLDRFDTAKEELFFNTRNRMSALTPNCSDMFVSCRIAGRLFD 237
            |....|.:| |::||.|....|                           .:||..||..:|.  .
  Rat   152 AAGLRYPEP-DMVDILNRTGHQ---------------------------LADMLKSCNFSGH--H 186

  Fly   238 C-MDKFETTLTSHGFCCTFNYDGRYVNKRDFRQRYFGPDMGLVLTLKTDPSDNFYKINGHNGYPD 301
            | ...|....|.:|.|.|||.|    .:.....|..|  ||..|.:..|.....|..........
  Rat   187 CSASNFSVVYTRYGKCYTFNAD----PQSSLPSRAGG--MGSGLEIMLDIQQEEYLPIWRETNET 245

  Fly   302 PFSGGVAERV---------------AETGFNTLLPVRAKIFETLPEARSMSPSVRKCLFENEMPW 351
            .|..|:..::               ...||.|.:..:.:....||:......:..| |.|.|:..
  Rat   246 SFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESK-LREPELQG 309

  Fly   352 IFARHYTFSKCISACRAQSVVSLCECVPFSLPHRYIDGSE----KRIYCTLQHLACLKRYEFKWL 412
            ..|  |:.|.|...|..::|:..|.|....:|     |:|    ..||     :.|
  Rat   310 YSA--YSVSACRLRCEKEAVLQRCHCRMVHMP-----GNETICPPNIY-----IEC--------- 353

  Fly   413 NVITSRENVTGLEHELQDAL--------YCPLCLASCTETRYSVRGAMTLGLPTPSQIKGPARSN 469
                       .:|.| |:|        :||   ..|..|||....:|         :|.|.|
  Rat   354 -----------ADHTL-DSLGGGSEGPCFCP---TPCNLTRYGKEISM---------VKIPNR-- 392

  Fly   470 PGPRANNSYGPASSSGSAKGPVHSSSAPAELAVVRIYFA------ETHIQ--------YFRQIIK 520
                           |||:                 |.|      ||:|:        :|..:..
  Rat   393 ---------------GSAR-----------------YLARKYNRNETYIRENFLVLDVFFEALTS 425

  Fly   521 SAW-----YETFSTIGNI---CGIIAGFSLIGICELLFFL-------AKQLWQACRAELRAELAH 570
            .|.     |...:.:|::   .|:..|.|::.:.|:|.::       .|::|:..:..||.....
  Rat   426 EAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGG 490

  Fly   571 I 571
            |
  Rat   491 I 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:459966	114/548 (21%)
Asic4	NP_071570.2	ENaC	40..488	CDD:273304	120/578 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	452..454		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..531