Protein Alignment ppk24 and SCNN1G

DIOPT Version :9

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001030.2
• Gene: SCNN1G / 6340
• HGNCID: 10602
• Length: 649
• Species: Homo sapiens
• Alignment Length: 643
• Identity: 116/643 - (18%)
• Similarity: 226/643 - (35%)
• Gaps: 196/643 - (30%)

  Fly    36 IRTLAPNHLPGTSAEDTRKLSFAAALKDLLQ----NLSFHCYSKLVESGRRIQERFFWFVFHITA 96
            |:.....:||.|..:       |..:|:|::    |.:.|...::|.|..|:: |..|..|.:||
Human     7 IKAKIKKNLPVTGPQ-------APTIKELMRWYCLNTNTHGCRRIVVSRGRLR-RLLWIGFTLTA 63

  Fly    97 LTVLIAFLWGTYTKEQEALVTTMYHPM-----YPIWKVEFPAISVCSLN---------------- 140
            :.::   ||      |.||:...::.:     ....|::|||:::|::|
Human    64 VALI---LW------QCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQ 119

  Fly   141 ----------------RISQRAAWQYAHNLSGKDPKQRNASH-----FYDQ-------------- 170
                            :..:..:|.     |..:.||...||     .:||
Human   120 ETREALKSLYGFPESRKRREAESWN-----SVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRK 179

  Fly   171 LKAFMYMYYDPSDLMDIDN--ALRFQ------------SFLDRFDTAKEELFFNTRNRMSA---- 217
            .|....:.:..|::|.|::  .:.||            :|....:..:|....:..|.|:.
Human   180 RKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLE 244

  Fly   218 ----LTPNCSDMFVSCRIAGRLFDCMDKFETTL---TSHGFCCTFNYDGRYVNKRDFRQRYFGPD 275
                ::.:..::.|:|...|  ..| |....||   ..||.|.|||   ...|:........|.:
Human   245 KKINMSYSAEELLVTCFFDG--VSC-DARNFTLFHHPMHGNCYTFN---NRENETILSTSMGGSE 303

  Fly   276 MGL--VLTLKTDPSDNFY------KINGHNGYPDPFSGGVAERVAETGFNTLLPVRAKIFETLPE 332
            .||  :|.:..:..:.|.      |:..|.....||...|...: ||...|.:.:.      |.|
Human   304 YGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEI-ETAMVTSIGMH------LTE 361

  Fly   333 ARSMSPSVRKCLFE-NEMPW--IFARHYTFSKCISACRAQSVVSLCECVPFSLP----HRYIDGS 390
            :..:|....:|..: :::|.  |:...|:...|:.:|....:|..|.|..:|.|    ..|.:..
Human   362 SFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQ 426

  Fly   391 E--KRIYCTLQ-HLACLKRYEFKWLNVITSRENVTGLEHELQDALYC-PLCLASCTETRYSVRGA 451
            :  ..:||..| |.|.                        :|:.|.| .:|..:|:...:::..:
Human   427 QHPNWMYCYYQLHRAF------------------------VQEELGCQSVCKEACSFKEWTLTTS 467

  Fly   452 MTLGLPTPSQIKG----PARS-NPGPRANNSYGPASSSGSAKGPVHSSSAPAELAVVRIYFAETH 511
            :.   ..||.:..    |..: :.|.:.|....                 ..:||.:.|::.:.:
Human   468 LA---QWPSVVSEKWLLPVLTWDQGRQVNKKLN-----------------KTDLAKLLIFYKDLN 512

  Fly   512 IQYFRQIIKSAWYETFSTIGNICGIIAGFSLIGICELL------FF--LAKQLWQACR 561
            .:...:...::.....|..|...|:....|::.:.|::      ||  :|::.||..:
Human   513 QRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAK 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	104/600 (17%)
SCNN1G	NP_001030.2	ENaC	24..630	CDD:273304	111/619 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152107
Domainoid	1	1.000	84	1.000	Domainoid score	I8228
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750