Protein Alignment ppk24 and SCNN1D

DIOPT Version :10

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 126/638 - (19%)
• Similarity: 200/638 - (31%)
• Gaps: 216/638 - (33%)

  Fly    20 AAWWIPNPGRVARYPPIRTLAPNHLPGTSAEDTRKLSFAAALKDLL----QNLSFHCYSKLVES- 79
            ||...|.||..:..||         |.........:...|:.::||    .|.:.|...:||.|
Human   188 AAQTPPRPGPPSAPPP---------PPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSR 243

  Fly    80 GRRIQERFFWFVFHITALTVLIAFLWGTYTKEQEALVTTMYH-PMYPIWKVE-----FPAISVCS 138
            |.|::.. .|   .:.:|..|:|..|     :...|....:| |:.....|.     .|.:::|.
Human   244 GNRLKTT-SW---GLLSLGALVALCW-----QLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCD 299

  Fly   139 LNRISQRAAWQYAHNLSGKDPKQRNASHFYDQLKAFMYMYYDPSDLMDIDNALRFQSFLDRFDTA 203
            .|                  |::                   ||.:      ||....||.|...
Human   300 GN------------------PRR-------------------PSPV------LRHLELLDEFARE 321

  Fly   204 KEELFFNT-----RNRMSALTPNCSDMF---------------VSCRIAGRLF-----DCMDKFE 243
            ..:..:|.     |..:||..|.....|               ...|:..||.     ||..:..
Human   322 NIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGY 386

  Fly   244 TT------------------------LTSHG-----FCCTFNYDGRYVNKRDFRQRY---FGP-- 274
            |:                        ..|||     |..:.:|||.....|.||..:   :|.
Human   387 TSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCY 451

  Fly   275 ---------------DMGLVLTLKTDP--------SDNFYKINGHNGYPDPFSGGVAERVAETGF 316
                           .:||||.::..|        :.....::|.|  ..||.|..:..| ..|.
Human   452 TVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRN--HTPFLGHHSFSV-RPGT 513

  Fly   317 NTLLPVRAKIFETLPEARSMSPSVRKCLFENEMPWIFARH---YTFSKCISACRAQSVVSLCECV 378
            ...:.:|.      .|...:......|....|...:...|   ||...|:.:|..|.:|..|.|.
Human   514 EATISIRE------DEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCG 572

  Fly   379 PFSLPHRYIDGSEKRIYC-TLQHLA---CLKR-YEFKWLNVITSRENVTGLE-HELQDALYCPLC 437
            .:.  |....|:|   || :.:|.|   |..| |:              .|| |.|.....||
Human   573 YYL--HPLPAGAE---YCSSARHPAWGHCFYRLYQ--------------DLETHRLPCTSRCP-- 616

  Fly   438 LASCTETRYSVRGAMTLGLPTPSQIKGPARSNPGPRANNSYGPASSSGSAKGPVHSSSAPAELAV 502
             ..|.|:.:.:.             .|.:|   .|.|.::....::.|....|..|....:.||.
Human   617 -RPCRESAFKLS-------------TGTSR---WPSAKSAGWTLATLGEQGLPHQSHRQRSSLAK 664

  Fly   503 VRIYFAETHIQYFRQIIKSAWY---ETFSTIGNICGIIAGFSLIGICELLFFL 552
            :.|.:.|.:   :|.:.::..|   :..|.:|::|.:..|.|::.:.|||..|
Human   665 INIVYQELN---YRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELL 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:459966	115/590 (19%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		8/31 (26%)
		ENaC	219..784	CDD:273304	117/598 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777