Protein Alignment ppk24 and SCNN1A

DIOPT Version :9

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 728
• Identity: 137/728 - (18%)
• Similarity: 219/728 - (30%)
• Gaps: 281/728 - (38%)

  Fly     4 EMESLDQKPFRLAVGRAAWWIPNPGRVA--------RYPPIRTLAPNHLPGT------------- 47
            ::|..|.:|.:          |.||.:.        ..||..|  |..:.|.
Human    44 KLEEQDPRPLQ----------PIPGLMEGNKLEEQDSSPPQST--PGLMKGNKREEQGLGPEPAA 96

  Fly    48 ----SAEDTRKLSFAAALKDLLQ----NLSFHCYSKLVESGRRIQERFFWFVFHITALTVL---I 101
                :||:...:.|..:.::|.:    |.:.|...:||.|.....:..||.|..:....::   .
Human    97 PQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQF 161

  Fly   102 AFLWGTYTKEQEALVTTMYHPMYPIW--------KVEFPAISVCSLN---------------RIS 143
            ..|:|.|..             ||:.        |:.|||:::|:||               ||:
Human   162 GLLFGEYFS-------------YPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRIT 213

  Fly   144 QRA---AWQY-------AHNLSGKD-------PKQ-----------RNASHFYDQLK-------- 172
            ::.   .::|       |.:.|.:|       |.|           |.|......|:
Human   214 EQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDW 278

  Fly   173 -----AFMYMYYDPSDLMDIDNALRFQSFLDRFDTAKEELFFNTRNRMSALTPNCSDMFVSCRIA 232
                 .|.....:.||..       :|::....|..:|...|:..|.:|.| |..........:.
Human   279 KDWKIGFQLCNQNKSDCF-------YQTYSSGVDAVREWYRFHYINILSRL-PETLPSLEEDTLG 335

  Fly   233 GRLFDCMDKFETTLTS-----------HGFCCTFNYDGRYVNKRDFRQRYFGPDMGLVLTLKTDP 286
            ..:|.|  :|.....:           :|.|.|||...   |...:.....|.:.||.|.|:.:.
Human   336 NFIFAC--RFNQVSCNQANYSHFHHPMYGNCYTFNDKN---NSNLWMSSMPGINNGLSLMLRAEQ 395

  Fly   287 SD---NFYKINGH----NGYPDPF---SGGVAERVAETGFNTLLPVRAKIFETL-PEARSMSPSV 340
            :|   ....:.|.    :|..:|.   .||...|   .|..|.:.:|.:..:.| .:....:.:.
Human   396 NDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLR---PGVETSISMRKETLDRLGGDYGDCTKNG 457

  Fly   341 RKCLFENEMPWIFARHYTFSKCISACRAQSVVSLCECVPFSLPH----RYID----GSEKRIYCT 397
            .....||    ::...||...||.:|..:|::..|.|.....|.    .|.|    .|....|..
Human   458 SDVPVEN----LYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYK 518

  Fly   398 LQ------HLACLKR---------YE--------------------------------------- 408
            ||      ||.|..:         |:
Human   519 LQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKV 583

  Fly   409 ---FKWLNVITSREN-----VTGLEH-----------------ELQDALY-----CPLCLASCTE 443
               ||.||..|:.|:     ||.|.:                 |:.:.::     ..|.|.....
Human   584 NIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFR 648

  Fly   444 TRY-----SVRGA-------------------MTLGLPTPSQIKGPARSNPGPRANNSYGPASSS 484
            :||     ..|||                   |:|.|..|.....||.:.| |.|..:.||..|.
Human   649 SRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAP-PPAYATLGPRPSP 712

  Fly   485 GSAKGPVHSSSAP 497
            |.:.| ..||:.|
Human   713 GGSAG-ASSSTCP 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:279230	122/642 (19%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	115/626 (18%)
		deg-1	121..631	CDD:273309	98/542 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152111
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750