Protein Alignment ppk24 and SCNN1A

DIOPT Version :10

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 732
• Identity: 139/732 - (18%)
• Similarity: 218/732 - (29%)
• Gaps: 289/732 - (39%)

  Fly     4 EMESLDQKPFRLAVGRAAWWIPNPGRVA--------RYPPIRTLAPNHLPGT------------- 47
            ::|..|.:|.:          |.||.:.        ..||..|  |..:.|.
Human    44 KLEEQDPRPLQ----------PIPGLMEGNKLEEQDSSPPQST--PGLMKGNKREEQGLGPEPAA 96

  Fly    48 ----SAEDTRKLSFAAALKDLLQ----NLSFHCYSKLVESGRRIQERFFWFVFHITALTVL---I 101
                :||:...:.|..:.::|.:    |.:.|...:||.|.....:..||.|..:....::   .
Human    97 PQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQF 161

  Fly   102 AFLWGTYTKEQEALVTTMYHPMYPIW--------KVEFPAISVCSLN---------------RIS 143
            ..|:|.|..             ||:.        |:.|||:::|:||               ||:
Human   162 GLLFGEYFS-------------YPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRIT 213

  Fly   144 QRA---AWQY-------AHNLSGKD-------PKQ-----------RNASHFYDQLK-------- 172
            ::.   .::|       |.:.|.:|       |.|           |.|......|:
Human   214 EQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDW 278

  Fly   173 -----AFMYMYYDPSDLMDIDNALRFQSFLDRFDTAKEELFFNTRNRMSALTPN----------- 221
                 .|.....:.||..       :|::....|..:|...|:..|.:|.|...
Human   279 KDWKIGFQLCNQNKSDCF-------YQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGN 336

  Fly   222 ----CSDMFVSCRIAGRLFDCMDKFETTLTSHGFCCTFNYDGRYVNKRDFRQRYFGPDMGLVLTL 282
                |....|||..|.     ...|...:  :|.|.|||...   |...:.....|.:.||.|.|
Human   337 FIFACRFNQVSCNQAN-----YSHFHHPM--YGNCYTFNDKN---NSNLWMSSMPGINNGLSLML 391

  Fly   283 KTDPSD---NFYKINGH----NGYPDPF---SGGVAERVAETGFNTLLPVRAKIFETL-PEARSM 336
            :.:.:|   ....:.|.    :|..:|.   .||...|   .|..|.:.:|.:..:.| .:....
Human   392 RAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLR---PGVETSISMRKETLDRLGGDYGDC 453

  Fly   337 SPSVRKCLFENEMPWIFARHYTFSKCISACRAQSVVSLCECVPFSLPH----RYID----GSEKR 393
            :.:......||    ::...||...||.:|..:|::..|.|.....|.    .|.|    .|...
Human   454 TKNGSDVPVEN----LYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGY 514

  Fly   394 IYCTLQ------HLACLKR---------YE----------------------------------- 408
            .|..||      ||.|..:         |:
Human   515 CYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNG 579

  Fly   409 -------FKWLNVITSREN-----VTGLEH-----------------ELQDALY-----CPLCLA 439
                   ||.||..|:.|:     ||.|.:                 |:.:.::     ..|.|.
Human   580 VAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 644

  Fly   440 SCTETRY-----SVRGA-------------------MTLGLPTPSQIKGPARSNPGPRANNSYGP 480
            ....:||     ..|||                   |:|.|..|.....||.:.| |.|..:.||
Human   645 RRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAP-PPAYATLGP 708

  Fly   481 ASSSGSAKGPVHSSSAP 497
            ..|.|.:.| ..||:.|
Human   709 RPSPGGSAG-ASSSTCP 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:459966	124/646 (19%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	117/630 (19%)