Protein Alignment ppk24 and Asic5

DIOPT Version :10

• Sequence 1: NP_651860.2
• Gene: ppk24 / 43702
• FlyBaseID: FBgn0039839
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_067345.1
• Gene: Asic5 / 58170
• MGIID: 1929259
• Length: 495
• Species: Mus musculus
• Alignment Length: 594
• Identity: 128/594 - (21%)
• Similarity: 217/594 - (36%)
• Gaps: 192/594 - (32%)

  Fly    28 GRVARYPPIRTLAPNHLPGTSAEDTRKLSFAAALKDLLQNLSFHCYSKLVESGRRIQERFFWFVF 92
            |::.||     |:...||  |..|.:|..     :|...:.|||....:.::..::: :..|...
Mouse    17 GKIKRY-----LSKRPLP--SPTDRKKFD-----QDFAMSTSFHGIHNIAQNQNKVR-KVIWLAV 68

  Fly    93 HITALTVLIAFLWGTYTKEQEALV-------TTMYHPMYPIWKVEFPAISVCSLNRISQRAAWQY 150
            .:.::::|:   |..|::    ||       ||.....| :.|:||||:::|:|||....|..::
Mouse    69 VLGSVSLLV---WQIYSR----LVNYFTWPTTTSIEVQY-VEKIEFPAVTLCNLNRFQTEAVSRF 125

  Fly   151 AHNLSGKDPKQRNASHFYDQLKAFMYMYYDPSDLMDIDNALRFQSFLDRFDTAKEELFFNTRNRM 215
                                  ..::..:|     .:...||.|........:.|.|.|.|.::.
Mouse   126 ----------------------GIIFFLWD-----IVSKVLRLQEISANNTGSPETLDFVTNHQN 163

  Fly   216 SALTPNC--------SDMFVSCRIAGRLFDCMDK-FETTLTSHGFCCTFNYDGRYVNKR------ 265
            .::|...        :|..|.|...|:  .|..| |:...|.:|.|.||||.....||.
Mouse   164 FSITEFVKNNGFYLNNDTLVHCEFFGK--TCSPKDFKHVFTEYGNCFTFNYGENIQNKNKVSVSG 226

  Fly   266 -------DFRQRYF--GP-----DMGLVLTLKTDPSDNFYKINGHNGYPDPFSGGVAERVAETGF 316
                   |..|..|  .|     |.|::..:             |:...:|...|:       |.
Mouse   227 RGLKLLLDVHQEEFTDNPVPGFADAGVIFVI-------------HSPKKEPQFDGL-------GL 271

  Fly   317 NTLLPVRAKIFETLPEARSMSPSVRKCLFENEMPW------IFARHY-TFSK--CISACRAQSVV 372
            ::.:.:.|::  |:.:.:::         ..|.||      |..|:: |:|.  |:..|:|:.:.
Mouse   272 SSPVGMHARV--TIRQLKTV---------HQEYPWGECNPNIKLRNFITYSTYGCLKECKARHIQ 325

  Fly   373 SLCECVPFSLPHRYIDGSEKRIYCTLQHLACLKRYEFKWLNVITSRENVTGLEHELQDALYCPL- 436
            .||.|:||.||...::       |.|          .::.|.::..     |:|..:..| |.:
Mouse   326 RLCGCLPFLLPGNGVE-------CDL----------LEYYNCVSPI-----LDHIERKGL-CTMG 367

  Fly   437 -----CLASCTETRYSVRGAMTLGLPT-PSQIKGPARSNPGPRANNSYGPASSSGSAKGPVHSSS 495
                 |..||.||.|..    |:...| |||           ||....        ||....|..
Mouse   368 THNSSCPVSCEETEYPA----TVSYSTFPSQ-----------RATRFL--------AKKLNQSQE 409

  Fly   496 APAE-LAVVRIYFAETHIQYFRQIIKSAWYETFSTIGNICGIIAGFSLIGICE------------ 547
            ...| |..:.|.:::.:.:..:|....:..|..:.:|...|:..|.|||.|.|
Mouse   410 YIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYFFTNFYWV 474

  Fly   548 LLFFLAKQL 556
            |:|||.|.|
Mouse   475 LIFFLLKIL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk24	NP_651860.2	ASC	65..551	CDD:459966	113/550 (21%)
Asic5	NP_067345.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30		6/19 (32%)
		ASC	41..466	CDD:459966	112/539 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)